| Episode Number | Episode Name |
Originally Aired |
Image |
| 1 | David Duchovny, Tim Gunn, Kevin Brennan | 2007-09-04 | |
| 2 | Clive Owen, Alan Alda, Dinosaur Jr. | 2007-09-05 | |
| 3 | Will Arnett, Terry Crews, Patti Scialfa | 2007-09-06 | |
| 4 | Jeff Garlin, Nicholas Art, Hot Hot Heat | 2007-09-07 | |
| 5 | Paul Giamatti, Alyson Hannigan, Bad Religion | 2007-09-10 | |
| 6 | Richard Gere, Sean William Scott, The Chesterfield Kings | 2007-09-11 | |
| 7 | Mary-Kate Olsen, Wayne Brady, Lyle Lovett | 2007-09-12 | |
| 8 | Billy Bob Thornton, Senator Christopher Dodd, Kenny Chesney | 2007-09-13 | |
| 9 | Patricia Heaton, Tiki Barber, The Used | 2007-09-14 |  |
| 10 | Morgan Freeman, Cheryl Hines, KT Turnstall | 2007-09-17 | |
| 14 | Meredith Vieira, Steven Wright, Ben Harper & the Innocent Criminals | 2007-09-21 | |
| 17 | Jamie Foxx, Heather Graham, Mike Birgbiglia | 2007-09-25 | |
| 19 | Dwayne "The Rock" Johnson, Ed Helms, Bjork | 2007-09-27 | |
| 21 | Jerry O'Connell, Ken Burns, VHS or Beta | 2007-10-01 | |
| 23 | Tina Fey, Kenneth Branagh, Ani DiFranco | 2007-10-03 | |
| 24 | Snoop Dogg, Connie Britton, Bloc Party | 2007-10-04 | |
| 25 | Jennifer Connelly, Fred Willard, Animal Collective | 2007-10-05 | |
| 27 | Mark Wahlberg, Michael Strahan, The Black Lips | 2007-10-09 | |
| 28 | Tracy Morgan, Emile Hirsch, A.J. Jacobs | 2007-10-10 | |
| 29 | Jon Bon Jovi, Eva Mendes, Klaxons | 2007-10-11 | |
| 40 | Bob Saget, Dwayne Perkins, Robert Gordon & Chris Spedding | 2008-01-02 | |
| 41 | Megan Mullally, Fonzworth Bentley, Kid Rock | 2008-01-03 | |
| 42 | Bill Maher, Jim Cramer, Mike Destefano | 2008-01-04 | |
| 43 | Hulk Hogan, Regina Hall, Nicole Atkins | 2008-01-07 | |
| 44 | Donald Trump, Irina Markova, Sia | 2008-01-08 | |
| 45 | Ice Cube, Dr. Drew Pinsky, Marah | 2008-01-09 | |
| 46 | Howie Mandel, Leigh Killian, Kate Nash | 2008-01-10 | |
| 47 | Brian Williams, David Wondrich, Doyle and Debbie | 2008-01-11 | |
| 48 | Lester Holt, Sue Johanson, Ingrid Michaelson | 2008-01-14 | |
| 49 | Tom Brokaw, comedian Anthony Jeselnik, Bell X1 | 2008-01-15 | |
| 50 | Pink, Lou Dobbs,Bettye Lavette | 2008-01-16 | |
| 51 | Chazz Palminteri, Erin Burnett, Louis XIV | 2008-01-17 | |
| 52 | Bret Michaels, New York Giant Antonio Pierce, Lisa Loeb | 2008-01-18 | |
| 53 | Jim Gaffigan, Chuck "The Iceman" Liddell, Joe Nichols | 2008-01-28 | |
| 54 | David Gregory, Travis Pastrana, Kate Walsh | 2008-01-29 | |
| 55 | Jeff Corwin, Colin Hanks, Matt Nathanson | 2008-01-30 | |
| 56 | Dr. Phil, David Borgenicht, Les Savy Fav | 2008-01-31 | |
| 57 | Shawn Thayer | 2008-02-01 | |
| 58 | Megan Mullally, Fonzworth Bentley, Kid Rock | 2008-03-01 | |
| 59 | Ann Curry, Mike Epps, OneRepublic | 2008-02-04 | |
| 65 | Matt Lauer, Ryan Reynolds, Simple Plan | 2008-02-13 | |
| 70 | Randy Jackson, Artie Lange, The Whigs | 2008-02-20 | |
| 73 | Will Arnett, Flavor Flav, Super Furry Animals | 2008-02-25 | |
| 74 | Will Ferrell, Rashida Jones, Fred Simmons | 2008-02-26 | |
| 76 | Natalie Portman, Robert Schimmel, James Blunt | 2008-02-28 | |
| 77 | Christina Ricci, Jason Sudeikis, Shooter Jennings | 2008-02-29 | |
| 80 | Snoop Dogg, Carson Daly | 2008-03-12 | |
| 81 | Meredith Vieira, Harland Williams, Keith Robinson | 2008-03-13 | |
| 82 | Frank Caliendo, Cheryl Hines, The Bad Plus | 2008-03-14 | |
| 83 | Martha Stewart, Lance Krall, Billy Bragg | 2008-03-17 | |
| 84 | Ice-T, Brian Posehn, Stars | 2008-03-18 | |
| 85 | Tracy Morgan, Chris Hansen, Paul Thorn | 2008-03-19 | |
| 86 | David Schwimmer, Drake Bell, Yael Naim | 2008-03-20 | |
| 87 | Ryan Phillippe, Big Show, JB Smoove | 2008-03-21 | |
| 88 | Bob Costas, Marc Maron, Moby | 2008-03-31 | |
| 89 | Helen Mirren, Wylie Gustafson, Carbon/Silicon | 2008-04-01 | |
| 90 | John Leguizamo, George Takei, The Bravery | 2008-04-02 | |
| 91 | John Krasinski, Bode Miller, Cobra Starship | 2008-04-03 | |
| 92 | Christina Applegate, Lewis Black, Stephen Curry | 2008-04-04 | |
| 93 | George Wendt, Howard Bach, Hot Chip | 2008-04-07 | |
| 94 | Jarod Miller, David Gregory, John Oliver | 2008-04-08 | |
| 95 | Eddie Izzard, Morgan Spurlock, Tapes 'N Tapes | 2008-04-08 | |
| 96 | Sarah Jessica Parker, Eddie Izzard, They Might Be Giants | 2008-04-10 | |
| 97 | Patrick Stewart, Oliver Hudson, A.A. Bondy | 2008-04-11 | |
| 98 | Rachael Ray, Kal Penn, Grizzly Bear | 2008-04-21 | |
| 99 | Andy Richter, Jennifer Esposito, She + Him | 2008-04-22 | |
| 100 | Seth Green, Peter Greenberg, Radiohead | 2008-04-23 | |
| 101 | Amy Poehler, Danica Patrick, Dave Attell | 2008-04-24 | |
| 102 | Tina Fey, Fred Willard, Say Anything | 2008-04-25 | |
| 103 | Marisa Tomei, Anthony Anderson, Santogold | 2008-04-28 | |
| 104 | Jeff Garlin, Dax Shepard, The Kills | 2008-04-29 | |
| 105 | Gordon Ramsay, Rob Corddry, Feist | 2008-04-30 | |
| 106 | Sigourney Weaver, Darrell Hammond, Was (Not Was) | 2008-05-01 | |
| 107 | Matthew Broderick, Michelle Monaghan, Brian Turner | 2008-05-02 | |
| 108 | Patricia Heaton, Katt Williams, Thrice | 2008-05-05 | |
| 109 | Jason Lee, Eva Amurri, Galactic | 2008-05-06 | |
| 110 | Liam Neeson, B.J. Novak, The Duke Spirit | 2008-05-07 | |
| 111 | Emile Hirsch, Terrell Owens, Craig Baldo | 2008-05-08 | |
| 112 | Seth Meyers, Sophia Bush, Tokio Hotel | 2008-05-09 | |
| 113 | Jimmy Fallon, William Shatner, Gary Vaynerchuk | 2008-05-12 | |
| 114 | Steve Carell, Alyson Hannigan, Duffy | 2008-05-13 | |
| 115 | Brian Williams, Leighton Meester, The Black Keys | 2008-05-14 | |
| 116 | Seth MacFarlane, Carlos Mencia, MGMT | 2008-05-15 | |
| 117 | Alan Alda, John Cena, Everest | 2008-05-16 | |
| 118 | Kevin Nealon, Mary McCormack, DeVotchKa | 2008-05-19 | |
| 119 | Denis Leary, Anthony Bourdain, Mates of State | 2008-05-20 | |
| 120 | Harrison Ford,Eric McCormack & Atmosphere | 2008-05-21 | |
| 121 | Kevin Spacey, Cynthia Nixon, Brian Kiley | 2008-05-22 | |
| 122 | Kristin Davis, Ira Glass, Ryan Bingham | 2008-05-23 | |
| 123 | The Strike Beard Show | 2008-05-27 | |
| 124 | Seann William Scott, Tim Meadows, The Raconteurs | 2008-06-02 | |
| 125 | Colin Firth, Hugh Rowland, Jackie Greene | 2008-06-09 | |
| 126 | Adam Sandler, Werner Herzog, Jewel | 2008-06-04 | |
| 127 | Wanda Sykes, Emmanuelle Chriqui, Lewis Black | 2008-06-05 | |
| 128 | Kim Cattrall, Matt Taibbi, Lightspeed Champion | 2008-06-06 | |
| 129 | Kate Hudson, Robert Smigel, James Hunter | 2008-06-09 | |
| 130 | Jeff Corwin, Mario Lopez, Jamie Lidell | 2008-06-10 | |
| 131 | Mark Wahlberg, Louis C.K., Sharon Jones and The Dap-Kings | 2008-06-11 | |
| 132 | Randy Jackson, Piper Perabo, Forever the Sickest Kids | 2008-06-12 | |
| 133 | Michael Strahan, D.L. Hughley, Brian Scolaro | 2008-06-13 | |
| 134 | Ann Curry, Mario Batali, The Lordz | 2008-06-16 | |
| 135 | Megan Mullally, Brittany Snow, Detroit Octane | 2008-06-17 | |
| 136 | Mike Myers, Jordana Spiro, Dolphina | 2008-06-18 | |
| 137 | Anne Hathaway, Romany Malco, My Morning Jacket | 2008-06-19 | |
| 138 | Jason Bateman, Masi Oka, Alejandro Escovedo | 2008-06-20 | |
| 139 | Ted Koppel, Emily Mortimer, Steel Train | 2008-07-07 | |
| 140 | Selma Blair, Sig Hansen, Little Jackie | 2008-07-08 | |
| 141 | Kyra Sedgwick, Jim Cramer, Joe Cocker | 2008-07-09 | |
| 142 | Al Roker, Paul Pierce, Pilobolus | 2008-07-10 | |
| 143 | Sean Hayes, Ed Helms, Tom Papa | 2008-07-11 | |
| 144 | Gary Oldman, Joe Buck, Kenny Chesney | 2008-07-14 | |
| 145 | Heidi Klum, Joel McHale, Daryl Hall and K.T. Tunstall | 2008-07-15 | |
| 146 | Seth Green, Russell Brand, Eugene Mirman | 2008-07-16 | |
| 147 | Aaron Eckhart, Caroline Rhea and Dr. Dog | 2008-07-17 | |
| 148 | Senator John McCain and The Steeldrivers | 2008-07-18 | |
| 149 | Kelsey Grammer, Keke Palmer, the Ting Tings | 2008-07-28 | |
| 150 | Jason Sudeikis, Dr. Wladimir | 2008-07-29 | |
| 151 | Kevin Costner, Maria Bello, Gogol Bordello | 2008-07-30 | |
| 152 | Kiefer Sutherland, Jim Gaffigan, Mason Jennings | 2008-08-08 | |
| 153 | Vin Diesel, Dave Attell, The Virgins | 2008-08-26 | |
| 154 | Tiger Woods | 2008-08-27 | |
| 155 | Nicolas Cage, Vivica A. Fox, Delta Spirit | | |
| 156 | Dr. Phil McGraw, Kevin Connolly, Adele | 2008-09-04 | |
| 159 | Keira Knightley, Tyler Perry, Bill Burr | 2008-09-09 | |
| 180 | Great Britain Guest Stars | 2008-08-25 | |
