An orange Cajun fox repeatedly tries to kidnap a sleepy Muriel so he can use her in a Cajun stew.
Courage and his owners stop at a lonely motel to end their vacation, but it is owned by a nefarious red cat named Katz, who harbors a penchant for feeding his guests to giant spiders.
Muriel is picking carrots out of the garden and feeds a rabbit one. She gets bit and only thinks it was a rabbit. They go to Dr. Vindaloo to find the cure. He just says to keep soaking it. She turns into a weremole, an animal who has a taste for biting people and rabbits. Once your bitten by one, you become one yourself. Courage must dress up as a rabbit, to get his attention, then pull a hair from the original weremole that bit her and feed it to Weremole-Muriel to turn her back to normal.
A scientist dies and his shadow spooks the town of Nowhere and then the Bagge's house. The shadow then admits he is tired of scaring people and decides to become a star in the sky, literally!
Bigfoot comes to the Bagge house. Courage and Bigfoot have a food fight, dance in Carmen Miranda outfits and have a good time. All the fun comes to an abrupt stop as soon as a mob of people arrive to get a reward for Bigfoot. Bigfoot's dad shows up and takes him home, without anyone getting hurt.
Muriel orders a new mattress and when she lays on it, a demon inside the mattress enters her body and takes over. Courage gets rid of the demon by finding a chant on The Computer. It exits Muriel's body and the mattress is sent back.
A Queen who lives in a puddle in the yard of the farm rises up out of the puddle. Eustace sees this Queen and decides to follow the hot chick. Little does he know that she is bad and plans to eat him. She drags him into the puddle, and Courage follows to save Eustace. She lives in a castle, which is where she plans to eat him. Courage saves him and gets out of the puddle as they just miss being captured.
Muriel's homegrown eggplants (that live underground) aren't getting enough water and try to attack her. Courage, after constantly trying, finally stops the eggplants from eating Muriel and give the eggplants water. Everything goes back to normal, and Muriel wins an award for the best eggplants.
Eustace gets a terrible foot fungus, and it grows until it takes over Eustace's body! The foot makes Courage steal money or else Muriel "gets it." Courage goes on the computer and finds out dog spit will get rid of the fungus. So, he licks the foot until it's gone and Eustace is back.
Courage, Muriel, and Eustace go on vacation to the North Pole. Courage goes out to get firewood and comes back to the igloo (where they were staying) and finds everybody else is gone. Courage knew it was a snowman because he saw it earlier. He figured out that the snowman was taking a liquid from Eustace and Muriel's body to be able to live in hot weather and not melt. Courage gets captured by the snowman but breaks out and saves both. The snowman falls into icy water while chasing them and freezes into a giant ice cube. Muriel, Courage, and Eustace go home.
Muriel is sick, so she sends Courage and Eustace to go to the bakery for her. Eustace gets in his truck and decides to go to eat first. He goes to a place called ""Burgers: Really Cheap!"". The owner is a pig named Jonn Bonne. He gives Eustace and Courage burgers. When Courage sees a guy come into a room and not come back, he thinks he was made into a burger because the burger looks just like him. He goes down and sees Jonn Bonne and his wife talking over a silhoutte of a person's head on a table! The Bonnes go after Courage, but he escapes through the mail slot and runs all the way home. Muriel has gotten better. It turns out the heads were really sculptures made of hamburger meat that Jonn Bonne makes. He, his wife, Eustace and that guy eat one of Eustace.
Courage notices a familar UFO come toward the Bagge's House. He sees a chicken (the same chicken from the pilot episode. Courage shot the chicken with a raygun and blew up the chicken's head) The chicken wantsa revenge, so he captures Muriel. Courage saves her before any harm is done. He captures Eustace and pulls off his head with a plunger! The chicken (with Eustace's head) chases Muriel and Courage, but later everything turns out OK with the exception of Eustace's missing head.
Little Muriel: Muriel is picked up by a tornado and is turned into a little kid. Courage has to put up with Little Muriel's antics and must find a tornado spinning the opposite direction to change Muriel back.
