Dave apologizes to Sue Hum for a pre-show accident; the show is interrupted by a performance of "Mark Twain Tonight!" starring Johnny Dark; Danny Devito plugs his new restaurant; Larry David (in his very first Late Show appearance) comments on Dave's hair; Avril Lavigne performs "When You're Gone."
| Name | Type | Role | |
|---|---|---|---|
| Avril Lavigne | Guest Star | ||
| Larry David | Guest Star | ||
| Jerry Foley | Director |