In Mexico the Colorado River now runs dry, partly because of climate change. Together with a team of environmentalists, Antonia, a member of the Cucapah tribe, is fighting to bring it back to life. When a deadly heat wave hits the area, Julio, a paramedic in nearby Mexicali, is on call to attend to the city’s most vulnerable. With 2021 set to be one of the hottest years on Earth, Life at 50°C presents the human impact of climate change.