Brain hatches a plot to hypnotize people, but he needs white crab meat to succeed. In order to get the crab meat, he takes a submarine to the wreck of the Titanic. Unfortunately, the CIA spots his sub and orders its destruction.
Brain plans to take over the world by creating a voice mail system that will tie up everyone on the planet long enough for him to take over. In order to do this he needs money. He decides to get it by getting a job and then staging an accident in order to sue the company.
Brain uses an enlarging ray to make himself and Pinky four hundred feet tall. With Pinky dressed as a Gollyzilla, Brain stages a fight to make himself look like hero. But then the real Gollyzilla shows up. / Brain makes Pinky smarter so his stupidity won't ruin anymore plans. / Pinky and Brain perform a song about the brain.
Brain gains the ability to cloud the minds of men with his voice. He tries to get on the radio by adapting the persona of "The Fog". Unfortunately his plan falls apart when he gets to the studio. / Brain hears that a space probe is about to be launched. On the probe is a plaque with a representation of man and woman. Brain changes the plaque to make it appear that he rules the world. Aliens discover the probe and take Pinky and the Brain to their planet where they honor them just like they are "honored" on Earth. / Pinky sings about cheese.
The Brain hatches a plan to take over the world by using static electricity to shock the world into submission. Unfortunately he needs several billion dollars to build a giant clothes dryer. Pinky and the Brain head to Island X where they set up a fake country and hope to get a giant foreign aid loan from the United States.
Brain develops a special pair of dentures that can produce a smile that can hypnotize anyone who is not wearing a special pair of sunglasses. In order to take over the world, he needs people to see the mesmerizing smile. He figures that he needs to get on TV and in order to do that he has to become a celebrity.
While France awaits Napoleon's triumphant return from Austria, Brain develops a recipe for exploding crepe-suzettes in an effort to conquer France. He uses the recipe in a cooking class and when the crepes explode, he is arrested. When he is taken to prison, however, his luck begins to change when people mistake him for Napoleon Bonaparte.
Pinky and the Brain head to the North Pole. Pinky just wants to see Santa, but the Brain has a more sinister plan. He wants pretend to be an elf so that he can mass produce a hypnotic doll named "Noddle Noggin" in Santa's workshop. He then hopes that Santa will distribute the toy all over world so he can take over.
Brain comes face to face with his former friend and now enemy, Snowball. And it seems Snowball has his own plans to take over the world.
In Victorian England, the Brain realizes that he can take over the world by becoming president of the "Pompous Explorers Club". since the position usually leads to the Prime Ministership of England. In order to become president of the club, he must make it around the world in seventy-nine days.
Brain plans to melt the ice caps with the Hubble Space Telescope once he buys everything higher than the 39th floor.
Brain hopes to take over the world by convincing everyone that Abraham Lincoln has been reincarnated. He takes up ventriloquism and plans on using a statue. / Brain tells a group of mice the story of "Don Cerebro" a mouse driven by his dream to take over the world.
Pinky searches for the Brain in post-World War II Vienna. He misunderstands people when they try to tell him the Brain is dead and his misunderstandings lead to a series of misadventures. / The Brain captures two mice for an experiment to aid in a plan for world domination. He discovers however that the two mice are his parents.
Brain tries to get all the people off Earth onto his paper mache creation, Chia Earth.
Using Johannes Gutenberg printing press, the Brain make a series of collectible trading cards. / A successful modern artist is born and it's Pinky, trying to help fund Brain's new plan.
Brain hopes his inter-galactic pen pal, Zalgar, will help him take over the world. But it turns out Zalgar likes to snack on brains.
Pinky writes a letter to the newspaper criticizing the comic strip "The Family Circus". His letter, however, is misunderstood as a political statement that thrusts him to a spotlight that leads him to the Presidency of the United States. Pinky's administration, however, must deal with a scandal when the Brain's plans to take over the world are made public.
Brain makes a tearjerker movie to make the world sad enough to make him leader.
Animal rights activist think Pink and the Brain are monkeys and release them into the jungle after taking them out of Acme Labs. The pair try to make it back home, but run into the Brain's old enemy Snowball.
Brain tries to discover what makes the legendary Sampson so strong. / When Brain comes to the conclusion he no longer wants to take over the world, he decides to help others who had his problem and the first one to be helped is Pinky.
Pinky and Brain get sealed in an Egyptian pyramid where a mummy is lurking about. / Brain gets a group of men to steal money from the rich (ala Robin Hood) to pay for his new plot.
Pinky and Brain stumble upon a super powered baby, who happened to arrive from an exploding alien world. / Pinky and Brain have to brave a virtual reality maze to find a microchip crucial to Brain's new plot.
The mice's future selves arrive in the lab, sending them on a roller coaster ride through time to find a world domination kit.
Pinky and Brain's DNA get merged during a cloning experiment, creating a new mouse.
Pinky and Brain put together a basketball team as part of their next plan, but the fame may be swelling Brain's head.
Brain enlists the aid of beavers to gain control over the flow of rivers. / The mice make a series of comedy films and hit the big time.
It's 1946 and Brain's new plan gets interrupted when he and Pinky encounter Billie and Snowball.
Pinky and Brain have a new companion, Larry, but their newest plan just doesn't seem to pan out. / In their latest plan, Pinky and Brain try to take over the steel mills in Pittsburgh, Pennsylvania by pretending to be a part of an endangered species called the Mousealopes.
Brain gets caught up in winning a golf tournament, even though it interferes with his new plan. / After the Earth gets the power of speech from his Silitronlinguifactor device, Brain comes up with a new plan.
Brain tries to get a package meant for him back from his neighbor.
Pinky becomes a guru during the 1960s. / It's Brain's birthday and Pinky plans a surprise party.
After getting a glimpse of his future, Brain abandons his attempts to take over the world and gets a job as a ski instructor.
The mice are looking to control tornados, but a pest keeps getting in their way.
Brain sings about past and present world leaders' failures. / The mice need to get into a mine, but have to pretend to join a Amish-type society.
Brain's latest plan is a conspiracy theory about why he is not ruling the world.
Brain becomes a tap dancer with steam-powered legs in order to spread a subliminal morse code at the World's Fair. / Brain is out of ideas for taking over the world, so he tries to get some from writers.
Farmer Brain tries to grow an army of monster vegetables.
Brain creates a cloning machine and plans to clone himself in order to create the best Celtic dance troupe the world has ever seen. / Brain masquerades as a fashion designer.
Brain plans to use the Personalitron to give him irresistible charisma, but it winds up going to Pinky. / The mice learn of a secret organization, T.H.E.Y. (comprised of world leaders), and try to get in.
A house needed for Brain's latest plot becomes the set of a reality series about the people living there. So the mice become participants to get in.
To save his Las Vegas casino, Brain works as a lounge singer.
Mr. Itch offers Brain control of the world in exchange for his soul, but Brain refuses. In a shocking twist, Pinky sells his soul to make it happen and Brain soon decides to get his friend back.
Brain assumes the identity of Briany Jack, a hippie leader, and tries to create a peace chain to send a subliminal message.
Brain's attempt to control Emperor Franz Josef get side tracked when he talks about his problems with psychiatrist Dr. Sigmund Freud. / Brain enters the world of a sumo wrestling to acquire a paralyzing fish.
Brain takes control of a satellite to air his infomercial around the world, but the satellite belongs to the military and they want to capture whoever hacked into their systems.
Brain takes control over aquatic mammals for his latest plan and Pinky falls for a female sea lion. / Brain tries to change the Earth's weather patterns.
A well-meaning tailor makes Pinky and Brain's lives miserable. / At a sleep away camp for world leaders' children, Brain tries to trick the children into placing listening devices in their parents' offices.
To release Brain's leather repellant, the mice become baseball players. / Brain's latest plan for world domination is the Schpiel-Borg 2000, which hosts a retrospective of past episodes.
Pinky and Brain stage their own seperate musicals, which have varying degrees of success.
Spoofing Winnie the Pooh, Brainie and Pinklet try to steal honey from a bee hive. / Brain tries to create chaos in Hamlet's family and take over.
Brain tries to become a national hero by taking down a tobacco company.
Taking the night off from trying to take over the world, Pinky and Brain try other things.
Brain enters Pinky's family in a contest to win $25,000.
Pinky has his own plan for world domination and Brain goes along with it. / Brain explains why he should be leader in a mock educational film.
As network executives keep repeatedly changing their show, Pinky and Brain decide to quit.
As he prepares his plan for world domination, Brain goes to work teaching rebellious students.
Pinky and Brain masquerade as a mother and child star respectively to get money needed for the next plan. / Pinky sings a song about saying "narf".
It's another usual night where Brain plans to take over the world, only it's seen from Pinky's point of view. / The mice sing about world domination. / Brain opens a restaurant and feeds the customers a drug to make them smarter.
Pinky and Brain are kidnapped in Washington, DC by an unknown force. Brain loses his memory and the mice are then imprisoned in a town where everyone is forced to perform the Schëerskåhøvên, which is dumbing down the entire country.
Brain regains his memory and the mice escape. They believe Snowball is responsible for the Schmëerskåhøvên, but him imprisoned in a mental institution.
The mice and Snowball search for the one who spliced their DNA, Dr. Mordough, thinking he's responsible for all this. But it turns out to be his cat, Precious, and time is running out.
Pinky and Brain's plan to alter caviar with a mutating capsule is complicated by a Russian lab mouse. / Brain plots to make every clock on Earth chime repeatedly.
A special of highlights of their career is on the air, but it's really all a ruse so Pinky and Brain can hypnotize the viewers.
Inspired by legends of the past, Brain tries to create a legend about himself to gain world acclaim. / How Acme Labs became home to Pinky and Brain.
In the series finale of Pinky and the Brain, the Brain, and the characters from Animaniacs develop a Star Wars spoof.
