When his henchmen fail to capture Swamp Thing, Dr. Arcane uses his Transducer machine to turn them into mutants to attack Swamp Thing. Two kids, Delbert and J.T. along with a game warden, Tomahawk and Bayou Jack with the help of Arcane's step daughter Abby come to Swamp Thing's rescue.
Dr. Arcane and his Un-Men travel to the Amazon Rainforest in search of “the trees that never die,” and enslaves a local Indian tribe to harvest their sap.
Swamp Thing, Bayou Jack, and Tomahawk help NASA retrieve a nuclear-powered satellite that has crash landed in the swamp. Meanwhile, Arcane desires the satellite for his own advantage.
Still obsessed on gaining immortality, Dr. Arcane desecrates the Indian burial of Tomahawk’s ancestors in search of the Lost Caverns, home of the fabled Fountain of Youth.
While showing Delbert & J.T. around the swamp, Swamp Thing is captured and taken to New Orleans for government experiments. Delbert, J.T., and Bayou Jack plan to rescue him as does Arcane for his own plans.