Investigative genetic genealogist CeCe Moore works with the New Madrid County Sheriff's Department on the 1998 murder of Sherri and Megan Scherer, a mother and daughter from New Madrid, Missouri. As the investigation takes Moore and detectives on a series of unexpected detours across the country, they uncover the identity of a previously unknown serial killer and Moore ends up meeting with the killer's daughter. The episode features interviews with Steven Scherer, son and brother to the victims; law enforcement from New Madrid and Greenville, South Carolina, and Memphis, Tennessee; the killer's daughter Deborah Brashers-Claunch; DNA expert Ruth Montgomery; and TV reporter Kathy Sweeney.