Tom and Manfred go back to medieval days to help a frail, timid knight--Sir Feeble Fred--win the hand of a princess by defeating a hulking bully of a knight in a jousting match.
Tom and Manfred must race Crabby Appleton (the show's primary villain--he's "Rotten To The Core") to retrieve the Pill of Smartness, an artifact sitting on the hand of Cleopatra that makes whoever swallows it the smartest person in the world.
Sweet Tooth Sam the candy bandit has stolen all the candy in town, making the children miserable. Tom and Manfred are on the hunt to retrieve the candy.
Tom gets mail from viewers of his cartoon show at the North Pole, who can get their local stations but not the network telecast from New York. Tom and Manfred go to the Empire State Building and rectify the transmitter's position.
Tom and Manfred find a pearl while fishing and plan to donate it to a shelter for homeless dogs. Crabby Appleton creates a dragon in order to retrieve a pearl from Tom's possession.
The pirate Captain Kidney Bean and his crew plan on pillaging a nearby village. As Tom and Manfred infiltrate the pirate camp, Kidney Bean throws Tom off his ship and makes Tom think that Manfred is siding with the pirates.
Isotope Feeny creates an anti-gravity device and tests it out in Manfred.
Tom and Manfred go back to prehistoric days so they can bring a dinosaur egg back to the museum.
Crabby Appleton causes directional chaos by stealing the North Pole, chopping it into segments and selling them as souvenirs.
Evil scientist Mr. Instant creates a powder that sends kids into fits of tantrums.
Tom teaches a bunch of small kids about confidence by staging a track meet for them. But bully Musclehead has other ideas.
Crabby Appleton has stolen all the weekends and holidays from the Nathaniel Annual Calendar factory, forcing continuous school for the kids and allowing Crabby unlimited rides at the fair.
In Africa, a lion has trouble making his presence known in the jungle because of an angry elephant scaring all the animals.
When Tom finds that mail from his pen pals haven't been arriving, he discovers that Crabby Appleton has been confiscating it.
Tom and Manfred visit Fairyland where they meet a handsome prince who was changed from being a frog and wants to be a frog again. The witch that made the spell sends Tom and Manfred on a quest for three... more objects in exchange for turning the prince back into a frog.
Isotope Feeny creates a cloud that turns whoever it engulfs into an idiot.
The moon's light has suddenly gone out. Tom and Manfred go to the moon where they find the Man In The Moon, who controls the moon phases, is quitting because he is always being buzzed by Earth's satellites.
Tom and Manfred go back in time where they help the last surviving pioneer to California.
The Sandman, the entity that puts children to sleep, has taken a vacation from his duties and it makes all the children in the world cranky for lack of sleep.
Crabby Appleton steals all the trees and creates his own private park with them.
While visiting Earth, Martians mistake Manfred for Tom Terrific, take him back to Mars and create a million clones of him.
Tom and Manfred must use the riddle posed by the Flying Sorceror in helping a genie return to his magic lamp.
Tom enters Manfred in a dog show, while Crabby Appleton seeks to sabotage Manfred's chances of winning by disguising himself as a dog.
Rainbow painter Rembrandt Van Rainbow has run out of color, so Tom and Manfred travel cross-country in search of more color for him.
Tom and Manfred travel to the bottom of the sea where they help Robins Nest Crusoe get his baseball uniforms so he can field his baseball team.
Crabby Appleton makes time repeat itself so his birthday party will go on forever.