After successfully working as the mercenary Deadpool for two years, Wade Wilson fails to kill one of his targets on his anniversary with Copycat (Marvel Comics), his girlfriend. That night, after the pair decide to start a family together, the target tracks Wilson down and inadvertently kills Vanessa. Wilson kills the man in revenge. He blames himself for her death and attempts to commit suicide six weeks later by blowing himself up. Wilson has a vision of Vanessa in the afterlife, but the pieces of his body remain alive and are put back together by Colossus (comics). Wilson is left with only a Skee-Ball token, an anniversary gift, as a final memento of Vanessa.
In this franchise that almost didn't happen, Ryan Reynolds stars as Wade Wilson, a former Special Forces operative who now works as a mercenary. His world comes crashing down when evil scientist Ajax tortures, disfigures and transforms him into Deadpool. The rogue experiment leaves Deadpool with accelerated healing powers and a twisted sense of humor. With help from mutant allies Colossus and Negasonic Teenage Warhead, Deadpool uses his new skills to hunt down the man who nearly destroyed his life.