Kate (Alexandra Daddario) and Meg (Kate Upton) are childhood friends and roommates in Seattle going through stressful times. Kate is a high school English teacher, bored of her regular curriculum and under pressure to quit by Principal Moss (Rob Corddry) who believes she should be in a different profession, causing her to think that he is firing her. Meg is a cosmetics saleswoman trying and failing to sell North Korean beauty products. After a night of drinking away their stress, the adventurous Meg suggests they go on vacation to get their groove back. The reserved Kate is reluctant, but ultimately acquiesces as Meg had already booked non-refundable tickets to Fort Lauderdale using Kate's frequent flyer miles.