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Weeds

2005
as Nancy Botwin

Red Sparrow

2018
as Stephanie Boucher

RED

2010
as Sarah

RED 2

2013
as Sarah Ross

Red Dragon

2002
as Molly Graham

Fried Green Tomatoes

1991
as Ruth Jamison

When We Rise

2017
as Roma Guy

Colin in Black and White

2021
as Teresa Kaepernick

Mr. Mercedes

2017
as Janey Patterson

R.I.P.D.

2013
as Proctor

Angels in America

2003
as Harper Pitt

Vinegar Hill

2005
as Ellen Grier

Let the Devil Wear Black

1999
as Julia Hirsch

Legalese

1998
as Rica Martin

Reckless

1995
as Pooty

Cupid & Cate

2000
as Cate DeAngelo

Pipe Dream

2002
as Toni Edelman

The Simple Life Of Noah Dearborn

1999
as Dr. Valerie Crane

Romance & Cigarettes

2005
as Constance

Hemingway

2021
as Mary Welsh

The Robber Bride

2007
as Zenia Arden

Howl

2010
as Gail Potter

Jamesy Boy

2014
as Tracy

The Portrait of a Lady

1996
as Henrietta Stackpole

Goodbye Lover

1998
as Peggy Blane

The Maker

1997
as Officer Emily Peck

Sugartime

1995
as Phyllis McGuire

Golden Exits

2018
as Gwendolyn

The Quality of Mercy

2002
as Sarah Richardson

The Client

1994
as Dianne Sway

Naked in New York

1993
as Joanne White

Behaving Badly

2014
as Lucy Stevens / Saint Lola

Solitary Man

2009
as Jordan

Murder in Mind

1997
as Caroline Walker

Saved!

2004
as Lillian

Saint Maybe

1998
as Lucy Dean Bedloe

Miracle Run

2003
as Corrine Morgan-Thomas

Guest Star

Episode The Late Show with Stephen Colbert
Mary-Louise Parker, Pusha T, The Record Company
2016
Episode Late Show with David Letterman
Mary-Louise Parker, Eugene Levy, Jet
2009
Episode Hallmark Hall Of Fame
Christmas in Conway
2013
Episode Late Show with David Letterman
Bill Hader, Mary-Louise Parker, The Walkmen
2012
Episode Chelsea Lately
Mary-Louise Parker
2009
Episode The Blacklist
Lord Baltimore
2014
Episode The Blacklist
Monarch Douglas Bank
2014
Episode Late Show with David Letterman
Show #2965
2008
Episode Conan (2010)
When Your Friend's Kid Just Starts Listing Dinosaurs, It's Okay to Give Him Beer.
2013
Episode The Blacklist
Dr. James Covington
2014
Episode Jimmy Kimmel Live!
Mary-Louise Parker; Idris Elba; Rhye
2013
Episode ITV at the Movies
Episode 5
2010
Episode The Blacklist
Dr. Linus Creel
2014
Episode The West Wing
The Last Hurrah
2006
Episode The Late Late Show with Craig Ferguson
Mary Louise Parker, Guillermo del Toro, Tori Amos
2009
Episode The Late Late Show with Craig Ferguson
Mary Louise Parker, Dom Irrera
2011
Episode Late Night with Seth Meyers
Andrew Garfield, Mary Louise Parker
2022