Psychology Professor Jackson Cooper Coop encounters a beautiful mystery woman, Natalie, he thinks could be his soulmate. After she disappears without giving Coop her full name or number, his best friend Carter tries to help him locate her.
Coop and Carter resort to social media to find Natalie, while his nosy neighbor Diane disapproves of their tactics. Carter helps Diane's nephew, Shadrach, with a personal problem. Coop's assistant, Sophie, hires an event planner.
Coop makes a last ditch effort to find Natalie using a private detective with questionable methods. Carter and Shadrach do some damage control when they break Coop's television.
Coop's latest hookup, Amy, becomes more than he can handle when she keeps turning up unexpectedly. Carter finds himself in a jam.
Coop offers dating advice to a British colleague and relationship advice to Sophie; Carter adopts a ferret; and Coop spots Natalie.
Coop and Sophie go to a psychology dept. retreat at the home of the dept. head, Dr. Harty, who also happens to be Scarlet's father. Carter returns to his childhood home and is forced to juggle his overbearing mother, Kitty, and his first love, Holly.
After a wild night, Coop and Carter both wake up with unwanted company. Coop's colleagues question his odd behavior. Carter tries to settle things with his high school sweetheart.
Carter hires Holly's sister to help with his memoir; Shadrach has bully issues; and Coop follows his therapist's advice and tries to put his past to rest.
After an unexpected development in her personal life, Sophie gets drunk at work on the day of the department gala. Coop rushes to cover for her and in the process encounters the event planner, Natalie.
Coop and Natalie go on a date, but things go south after they return to Coop's place; Carter loses Zoe; Sophie needs help working things out with Jeremy; and Diane goes into labor.