Clinton Kane and Mooski got their first debuts. Kali Uchis, NF, and Tiësto made their returns. Along with the excruciating comebacks from Kodak Black & 6ix9ine. Also, the two songs from the deluxe albums of Pop Smoke and Ariana Grande, respectively.
| Name | Type | Role | |
|---|---|---|---|
| Pop Smoke | Musical Guest | Himself | |
| Ariana Grande | Musical Guest | Herself | |
| Clinton Kane | Musical Guest | Himself | |
| Kali Uchis | Musical Guest | Herself | |
| NF | Musical Guest | Himself |