Psychiatrist Spence Mackay is struggling to cope after the loss of his wife and son in a car accident. But what if their deaths were not accidental? And what is really lurking under the surface of Canal Road, the medical institute where he works? All of these thoughts come bubbling to the surface with the arrival of Greg Manor to the Canal Road clinic. Manor was the one responsible for the deaths of Spence's family, and upon seeing him takes matters into his own hands. But what chilling statement will Manor mutter that will make Spence's blood run cold?
After Holly saves a traumatised drug addict, Tracey, from her violent parolee boyfriend, Colin, she finds herself the target of a frightening stalking campaign, and suspects it too be the smooth, but violent, Jack Logan. Spence receives a series of security camera photos of himself, including one of him and Greg Manor, from an anonymous source. A threat or a warning? His inability to track down the sender of the photos renders him unable to find out more about Ellen and Toby's mysterious deaths.
Olivia's personal and professional lives collide when a troubled former friend, Bianca, re-enters her life. Spence is enraged to learn a drink driver has received a more severe sentence than the man who killed his wife and son in a car accident.
Steve's attempt to land himself a high-profile case backfires when he falls into old habits and has sex with a gorgeous young client, as well as her mother. The father of one of Spence's patients is intent on learning what his daughter has confided to Spence in his capacity as a psychiatrist.
Holly Chong's relationship with parolee Jack Logan is proving difficult to keep a secret, especially when he flirts with her at Canal Road. Steve compromises his integrity by stealing some of Spence's patient files.
Bridget is on a slippery slope, she's been arrested for vandalism, evicted from home, and now she owes money to everybody including her drug dealer. Meanwhile, Spence is forced to reassess his life when he learns his late wife Ellen had been having an affair, and Olivia breaks off her casual relationship with Tom
Skye's world is rocked when her sister is found murdered. Meanwhile, Spence is being harassed by an unpredictable former patient, whom he believes is the killer. And, Olivia is shocked when Tom charges her with workplace sexual harassment.
A beautiful clairvoyant, who claims that voices of the dead made her attempt to kill her father, starts channelling the voice of Spence's dead wife. Could this be real, or is it an elaborate hoax to avoid a murder charge?
Bridget and the staff at Canal Road try to discover the identity of a homeless man with no memory of who he is. It is a mystery that only deepens when an attempt is made on his life. A man with a link to Spence's past holds all of the answers but the truth once revealed leaves Spence with only more questions.
Despite claiming her relationship with convicted thief Jack Logan over, Holly is secretly planning to break her man free. However, her elaborate plan goes progressively off the rails, and Spence convinces Jack into giving himself up. Tom inexplicably finds himself in a love triangle with two dancers.
Skye is infuriated when she learns that police still have not found the person who murdered her sister. She embarks on a quest to find the killer, while the rest of the staff become increasingly concerned for her safety. The return of a mate from Henry's past causes him to question his life while Steve tracks down the person who stole his identity.
When Bridget becomes mysteriously ill, Olivia suspects her drug-using party lifestyle is to blame. But as her symptoms worsen, Bridget becomes convinced that her flatmate Daina is poisoning her.
Convinced he has solved the mystery of his wife and son's death, Spence feels free to explore a relationship with ex-patient Daina Connelly. But, Olivia becomes convinced that Daina, not Daina's late father, is the serial killer responsible for a spate of deaths over the past few years including Spence's wife and son.