When a top-secret weapon is stolen in broad daylight from a U.S. defense contractor, CIA agent Colin Glass is paired with FBI agent Bill Goodman to investigate. Their new partnership gets off to a rocky start, but they soon realize their opposing viewpoints may be their greatest asset.
When a known smuggler is flagged at the New York border with unidentified cargo, Colin and Bill head upstate to track. To find this smuggler, they must enlist the help of a foreign intelligence officer looking to defect.
When a deeply embedded U.S. intelligence officer is detained in Hong Kong, Nikki insists on traveling there to bring him home. But when her cover is blown, the team must work tirelessly to get her back to New York.
When a wanted Belarusian national is discovered posing as an expecting father, Colin and Bill work to expose an international illegal baby smuggling ring. Meanwhile, Bill worries about his father's health back home.
After a cyber engineer and her family are killed in a targeted attack, Colin and Bill rush to stop the culprits before they strike again.
After Colin receives a tip on an upcoming terror plot, the team recovers a young man who was kidnapped nine years ago in Turkey and dig into his time in captivity to help stop the attack. Meanwhile, Bill looks into someone very close to Colin.
When handling security for an international soccer game, a bomb threat leads Colin and Bill to discover two players who are being hunted after they go missing. As the case evolves, the team leans on FBI's Special Agent in Charge Isobel Castille and Special Agent Maggie Bell for assistance.
When a crashed satellite containing dangerous nuclear material disappears, Bill and Colin work with an undercover Gina to recruit the help of a retired arms dealer to help track it down.
A woman with intel on a dangerous terror leader connects Colin and Bill to a family business engaged in terror operations. Now, they must find and turn a new asset to take down the entire operation. Meanwhile, Bill makes a shocking discovery.
When a foreign diplomat is killed after sneaking into the U.S. under unknown circumstances, Colin and Bill discover that a rare mineral with potential to disrupt international relations may be the reason he was targeted.
When Colin learns his CIA mentor has gone dark, he enlists Bill and the team to help track them down. But as they get closer, the operation reveals significant information about the identity of the mole.
Colin and Bill race to stop a company from covering up their intelligence theft while taking down a dangerous person from Colin's past.
A known cartel fixer arrives in New York City, and as the team gets busy tracking him down, they discover the body of a dead DEA agent. After it becomes clear the case is not what it seems, the team must work quickly to prevent additional murders. Meanwhile, Bill makes a shocking discovery when he returns to work after the death of his father, and the team enlists the help of FBI's Special Agent Stuart Scola.
After a Russian spy is poisoned by his own comrades, he offers to help the team neutralize a threat against U.S. assets in Russia in exchange for the dying spy’s final wish: revenge.
In order to stop a terrorist cell carrying out a chemical bombing at an unknown location in the city, the team joins forces with an old school code breaker who is suffering from agoraphobia. Together they decipher a seemingly unbreakable cipher. Meanwhile, Colin wrestles with Toni’s return to the field, and Bill braces for Katie’s response to his recent admission.
