A foul-tempered farmer has trained his German Shepherd dog to attack any and all animals from the Wameru reserve. Paula and Jack Dane find the animal caught in a poacher's snare, rescue it, and take it back to Dr. Tracy to be treated and, more importantly, re-trained—a prospect that's not likely to sit well with the dog's owner.
Clarence the lion, normally a gentle soul, starts acting oddly after receiving a blow to the head in a jeep accident, becoming edgy, hard to control and growling at everybody. Dr. Tracy suspects that the blow has given Clarence amnesia, a diagnosis seemingly confirmed when Clarence suddenly takes a nasty swipe at Paula.
A pregnant black leopard with a history of killing her previous cubs and attacking her trainer is brought to the center in hopes that Dr. Tracy can change her behavior. However, Judy the chimp fails to lock the leopard's cage and she escapes. Paula is forced to play midwife when she finds the leopard in the bush about to give birth.
Paula and Dr. Tracy work to remove wildlife from an area soon to be flooded when hydraulic engineers dynamite a levee. An impatient engineer, not knowing that Paula is in the area and annoyed over the time lost saving animals, sets off the dynamite ahead of schedule, releasing a wall of floodwater and endangering Paula's life.
Hedley accompanies an officer and his Nazi prisoner on a mission to locate microfilm evidence against the Nazi and his cohorts that is supposedly buried on the reserve. However, the officer and prisoner are actually two former German soldiers looking for a cache of buried diamonds. Their plan goes awry when Hedley gives the package of diamonds to Judy the chimp, who hides them.