Nine pairs are cuffed together as the experiment begins. There's a sweary bar-tender and a millionaire. An alpha male and a proud feminist. Who'll be first to take the cuffs off?
Self-confessed prude Charlie is cuffed to heavily-tattooed Rob. Can Christian hairdresser Nina learn how to deal with her cuff-partner Sara's extreme chattiness?
Horse trainer Claire, who believes in the countryside and hard work, is paired with model and content creator Bambi, who loves the city and the easy life. Can Bambi cope with Claire's busy schedule?
Can an eco-warrior and a petrol-head beauty salon owner agree to disagree on the environment? And a country-loving Yorkshireman shocks a London youth worker to his core.
The cuffed pairs take off on a road trip. Away from home and family, just the two of them and the iconic, idyllic Great British outdoors - naturally, tempers flare.
It's the final. With £100k at stake, the pairs must race each other across the UK. How do they work together? Do they bond? Or do tensions boil over? And who'll be Handcuff champions?