A man is found dead after having been robbed by a motorcyclist with a gun, and McGarrett is shocked to discover that the man was suffering from bubonic plague. The islands are quarantined, and the team must follow a series of clues to discover the cause of the outbreak.
| Name | Type | Role | |
|---|---|---|---|
| Robert C. Dennis | Writer | ||
| Hai Luen Corragio | Guest Star | ||
| Nancy Kovack | Guest Star | ||
| David Opatoshu | Guest Star | ||
| Arthur Hee | Guest Star | ||
| George 'Keoki' Awai | Guest Star | ||
| Herb Jeffries | Guest Star | ||
| Norman Wright | Guest Star | ||
| Ed Sheehan | Guest Star | ||
| Victor Sen Yung | Guest Star | ||
| Soon-Tek Oh | Guest Star | ||
| Yankee Chang | Guest Star | ||
| Allan Tan | Guest Star | ||
| Jackie Coogan | Guest Star | ||
| Richard Benedict | Director |