Together with Saki, Jin frantically treats Ohatsu even as it seems like his own body is going to disappear. He vanishes before Saki’s eyes and in that moment, he sees something …
Back in Edo, Jin’s struggle has been in vain. Ohatsu loses her life … and he is overcome by a feeling of hollowness. Jin returns to Jinyudo with Saki, where they learn from Katsu that Ryoma had been attacked at Teradaya. Painfully aware of his own powerlessness, Jin is alarmed by Ryoma’s looming assassination …
Meanwhile, Tanosuke visits Jin at Jinyudo to entreat him to examine his senior apprentice, Bando Kichijuro, who has been bedridden as a result of illness. Because Kichijuro has Raynaud’s syndrome (a disorder of blood circulation in the fingers and toes which aggravates with exposure to the cold), his fingers and toes have become ulcerated and need to be amputated in order to prolong his life. However, Kichijuro wishes to stand on stage and perform a play one last time. He pleads with Jin to let him recover his mobility for a month. Although Jin has his doubts, he decides to respect the wishes of his patient, and works hard together with Saburi and the other doctors to ease the illness. But …
薩摩藩預かりの身となった坂本龍馬（内野聖陽）は、仲間と共に「亀山社中」という海運商社を立ち上げる。さらに、同じく土佐の脱藩浪人で、長州藩の預かりとなっている中岡慎太郎（市川亀治郎）と出会い、意気投合。二人で長州と薩摩の和解を目指し、走り回っていた。ある日、ペニシリンの粉末化を模索している南方仁（大沢たかお）の元へ、多紀玄？（相島一之）がやって来る。
南方仁於下榻旅館認識的少女小初，在遊玩時跌倒受傷。仁與小咲著手治療阿初，沒想到仁的身體竟然開始消失...
澤村田之助為了臥病的師兄坂東吉十郎，前來拜託仁能夠幫忙治療。吉十郎的手腳指開始潰瘍，為了保命必須截肢，但吉十郎卻希望能最後一次站上舞台...
