During her second year of weight-loss, Zsalynn is torn between fighting her weight and fighting for her marriage. Christina lets go of the negative influences in her life and is finally able to live the life of a twenty-something.
Olivia strives to weigh-in under 200-lbs as she lives by herself for the first time and suffers an unexpected loss. Battling a series of let downs, James fights to reach his goal of skin surgery and to live a fulfilling relationship for the first time.
Away from Dr. Nowzaradan's care, Penny has returned to Maryland believing she can make the choices to lose weight, but has she truly changed? Dating for the first time in her life, Tara continues to lose weight and is learning to balance new roles.
Chuck starts from scratch during his second year of weight-loss, discovering a promising new relationship. Paula juggles many responsibilities at once, but is it too much to stay on track for her weight-loss goal?
Melissa finds herself overwhelmed with four children, a marriage on the rocks, and an unexpected pregnancy. When Ashley's weight loss journey hits a wall, she sets out to find new inspiration to get herself back on track towards a healthy lifestyle.
Christina's weight loss has gone too far, too fast, and now threatens her life. After losing 300 lbs, Paula must endure more surgery to deal with a body entirely covered in loose and sagging excess skin.
Zsalynn is excited for a fresh start but her 360-body lift at a Beverly Hills clinic proves more challenging than expected. Lonely and depressed since her gastric surgery, Olivia wants skin removal surgery but struggles to lose the weight to qualify.
Betti Jo battles depression and a cancer diagnosis and when she finds out she's pregnant, she and her husband must find a way to cope. Susan suffers a major setback after surgery for her excess skin, thwarting her hopes to conquer her obesity.
Joe has come a long way from being morbidly obese: He's in love and contemplating proposing to his girlfriend. Just when life holds so much promise, his mom has few health scares and forces Joe to balance his new love with his mother's health crisis.
Despite having lost 378 lbs, Angela's knee pain combined with a history of obesity threatens everything she's worked for. Charity must find the strength to return to her goals of getting healthy.
Laura has lost 300 lbs + and is much less dependent on her husband Joey, who is now having trouble finding his way in the relationship. Marla, one of Dr. Now's most challenging patients returns and the fireworks begin all over again.
Pauline must find the will to keep up her weight-loss progress after a medical emergency. Chay's finally admitting what he's long known, that he's a transgender woman. But, the emotional stress of coming out could threaten his weight loss journey.
Dr. Nowzaradan is worried Lupe's emotional issues are blocking her weight loss journey since she's shed over 300 lbs but still can't walk. When Ashley is struck with sudden paralysis, her own emotional stability is thrown into peril.
Gastric surgery freed Brittani from her housebound life, but to achieve her ideal body she'll have to endure two more painful surgeries. Sean's super-obesity nearly killed him...Will he finally make a break from his mother's over-protective care?
Surgery enables Teretha to finally return to family in Detroit but it soon threatens to undo all the progress she's made. After his weight loss surgery, trucker Chad gets back on the road, but the job is putting any further weight loss in peril.
After losing 250 lbs, Nikki is on her way to skin surgery that will transform her body. But when a close friend dies from weight loss surgery, Nikki's progress goes off track, derailed by fears of another surgery and if she'll make it out alive.
Devastated by the sudden loss of her son, Dottie's weight loss journey is in danger of going off track. After her gastric bypass surgery, June embarks on a plan to win approval for skin surgery and start living the life she always dreamed of having.
Charity managed to lose over 400 pounds, but now her daughter Charly is becoming dangerously obese. Can Charity help her avoid the same fate? Devastated by the death of her husband Elroy, Milla must find a way to finally qualify for gastric bypass.
Joe was once 800 lbs, housebound and alone. Now engaged and planning a wedding, can he continue his weight loss? After losing over 300 lbs, Pauline is on the verge of independence if only she can qualify for the skin surgery she needs so badly.
Surgery enabled Laura's independence but the complications nearly killed her and she's terrified about the skin surgery. Chay revealed to her family she was transgender but living life as an overweight woman; can she stick to her weight loss journey?
Steven Assanti's dysfunction escalates, pushing his relationship with Dr. Nowzaradan to the brink, and a risky decision is made to save Steven's life, while brother Justin takes the leap to go to Houston to finally accept help.
At 400 lbs Bettie Jo achieves a dream, she's pregnant. But the pregnancy is soon in jeopardy. Will she deliver the baby without complications? Susan lost 400 lbs and she's in a relationship. When weight loss stalls, can she turn things around again?
11 years later, Melissa has lost 500 lbs and saw her weight drop to 137 lbs. Now facing marital problems, three pregnancies, and life as a single mom, Melissa is struggling with a 150 lb weight gain. Melissa is at a crossroads; can she find her way?
After successful sleeve gastrectomy procedures, the Dreier twins collectively lost more than 400 lbs and are working toward skin surgeries when a major life event disrupts their world and threatens the security they thought they had.
Erica must return to California to continue her weight loss journey but fears past emotional trauma will derail her progress.
Ashley lost over 200 lbs in Houston, but can she regain independence and continue to lose back in California with her enabling family? No longer a shut-in, Diana has embraced her new life and shed 300 lbs, but will knee damage threaten her progress?
Kirsten must become independent to get the full gastric bypass surgery she feels she needs. Michael struggles to lose and still battles anger issues while his wife, Roni, wants her own surgery. Will they both succeed or falter under the stress?
Back on Dr. Nowzaradan's program, James is suspected of cheating as he continues to gain weight and suffers a series of life-threatening illnesses; Cynthia continues to lose weight but seems satisfied to do so at her own pace.
Losing over 200 pounds, Doug is now an active part of his family's lives and inspires a healthier lifestyle for them all. However, Doug's eating disorder and trouble finding his own identity threaten to derail his progress.
Ashley has hit an emotional wall and is desperate for skin surgery but the problem is that she's not losing any weight. After being evicted, Nicole is forced to move back to Ohio which could impact her weight loss journey.
Brittani has lost over 400 pounds in two years. As part of her next chapter, will she and Bill start to plan to expand their family? Lupe has struggled since surgery. Having left her husband, will she finally start to make the permanent changes she needs?
Sean must overcome recent tragedy's in his life before he loses all the progress he's made over the last two years. Dottie struggles to stay on track while maintaining her family life and dealing with new pains in her body.
Milla is still completely dependent on her children. Will she finally lose enough weight to be able to walk? Charity is in a deep depression while her daughter is battling food addiction. Can they turn things around and reach their goal weight?
As Steven heals from his weight loss surgery his brother Justin finally decides to come to Texas to get the same procedure but his feelings towards Steven immediately begin to sabotage his hopes of surgery.
A year since her weight loss journey began, Janine is still in the 500 and mostly immobile, and now, Dr. Nowzaradan is running out of options to treat her if she can't find a way to control her eating habit and start walking again,
Lee's anger issues continue to jeopardize his relationship with Rena and threaten to derail both of their weight loss journeys; a major life event sends Sarah into depression, and she must pull herself out of it if she wants to keep losing weight.
In the 4th year of his weight loss journey, Sean struggles to get past the loss of his mother and live on his own. Dr. Now intervenes to control his eating for a time, but if Sean can't learn to control himself, he will face dire consequences.
Liz has gone from being bedbound with lymphedemas on both legs, to standing and walking, but old fears are about to threaten her progress. And if Jenn and Marissa can't get along as mother and daughter to lose weight, they'll have to proceed apart.
For Milla Clark, after 3 years & 5 surgeries, success would mean beating the odds, and becoming one of Dr. Nowzaradan's most impressive weight-loss patients ever. Failure would mean slipping back to the bedbound life she swore she'd never return to.
Pauline's self-destructive behavior continues to be a problem. Chad strives to be a better father and husband as he continues his journey. June's progress stalls when frequent travel and wedding plans cause her to slip back into bad habits.
Tamy faces a tough choice when her husband wants her back but only if she moves away from Houston and Dr. Now's program. Karina's weight loss begins to slow, but she finds happiness dating a guy Dr. Now is surprised to see in his clinic again.
In year three Erica is succeeding on her weight-loss journey with romantic misfortune send her spiraling backwards; Benji Bolton must reach his goal weight without the support of his brother David after a disagreement leaves the brothers estranged.
Alicia’s relationship with her boyfriend comes under the microscope in the second year of her weight loss journey; now in her fourth year, Pauline must beg her way back onto the program after quitting when her last weight in didnt go so well.
Dottie faces an unexpected challenge to her weight-loss when her husband's drinking problem becomes intolerable for her and her son. Cynthia starts to wonder if being there for her kids at her current weight is more important than losing more.
In order to keep pace with her daughter Charly’s weight loss, Charity must do something she’s never done: find a way to go it alone; try as she might, Teretha finds one too many obstacles in the way of continuing with Dr. Nowzaradan’s program.
Together weighing more than a ton, the Perrio siblings Roshanda, Brandie and Clarence set out to lose weight as a family; the all-for-one approach may be hurting more than it helps when each of them shows signs of heading in the wrong direction after surgery.
If Steven Sr. thought getting weight loss surgery for his sons would help bring them together, the 3rd year of their weight loss journey will prove him wrong, as Justin returns to Rhode Island with every intention to never speak to Steven again.
Maja needs weight-loss surgery so she can lose weight, but Dr. Now won't approve her for surgery if she can't overcome getting dumped by her boyfriend Christian without using food to cope. Justin charts a course to be one of Dr. Now's best patients ever.
There is much to be gained -- and lost -- for Brianne in year two of her journey, in which she both loses weight and gains independence. Getting back with Erica becomes the top priority for Annjeanette, who chooses love over even her own health.
Right when Angie starts to succeed in Dr. Now's program, her marriage falls apart and her life is thrown into chaos. Angie moves ahead despite dire difficulties, but when her body starts to break down, Angie fears the worst ... and faces it alone.
Angie enters the most-trying stretch of her weight-loss journey. She finds herself on the brink of homelessness after Dr. Now refuses to keep her in his programme unless she submits to drug rehab for substance abuse.
Jeanne struggles to care for herself in the aftermath of her dad's death. Brandon strives to get his weight down in order to feel confident when proposing to his girlfriend Tayler and be the man she deserves.
Cillas must face difficulties from his childhood in order to progress to his goal weight and set an example for his children. Tiffany struggles to lose weight when financial hardships place a strain on her relationship with her boyfriend Aaron.
The brothers shock Dr. Now with their staggering collective weight loss.
Holly has come a long way in her weight loss journey, but now she's trying to balance a wedding and skin surgery. Lashanta struggles to lose any weight at all. When a car drives through a wall in her living room, her weight loss is curtailed even more.
Robin and Garrett started their weight-loss journeys together as aunt and nephew. Now almost four years later, they continue to support each other to reach their target weights by shedding pounds and having skin removal surgeries.
Vianey and Allen have been on a weight loss journey together. But after Allen's surgery is a success and Vianey's is not, the couple struggles to get back on the same page to save their lives.
After regaining her mobility, Octavia is determined never to be stuck in the bed again, but difficult life circumstances threaten her ability to eat right and stay on track. Aaron is laid low by the death of his father, but true love saves him.
Even after surgery, Lacey's weight loss moves at a glacial pace. She says she wants skin removal surgery, but Dr. Now begins to wonder if she even wants to lose weight. Meanwhile, abandoned in Houston by her cousin, Mercedes and her kids face destitution.
