A firefighter searches for answers to his respiratory problems; a nurse experiences internal bleeding.
A child is discovered to have Celiac disease and with it, an intolerance to gluten - a normal ingredient in most breads and whole grains. A woman has her left frontal lobe removed, and is seizure free.
Haley Daquara is born with Hurler's disease and undergoes a stem-cell transplant procedure; a woman is diagnosed with myasthenia gravis.
Doctors investigate why a young boy's body is not producing the right antibodies to fight off germs and infections; A cancerous tumor which forms between a man's stomach and small intestine must immediately be removed. A woman loses the ability to walk.
A young girl is diagnosed with an extremely rare disease called Trigeminal Neuralgia that causes shock-like pain in the face. A woman searches for answers after she gains 100 lbs. in three months, gets skins tags, horrible acne, and stops menstruating.
Abdominal pains and severe headaches plagued 12-year-old Marissa Irwin until doctors diagnosed her with a retroflexed odontoid and Chiari One Malformation. A firefighter and paramedic is diagnosed with AIDS.
Five-year old Connor Rowley is plagued with a mysterious fever that won't go away. Along with this comes a stomachache that is just as resilient. Doctors are baffled and Connor is getting worse. Can doctors find out what is wrong before it's too late?
Joanne Zeis begins to see things floating in her field of vision. Over the next 17 years, Joanne's symptoms worsen. She suffers from joint pain, mouth ulcers, genital sores, and skin lesions. Will the physicians be able to properly diagnose her in time?
Like most proud parents, Ray and Jenny Moyer are ecstatic when their daughter Daphne is born. But soon after Ray and Jenny bring Daphne home from the hospital, she becomes irritable, has trouble nursing and stops gaining weight. What could be wrong?
Mary and Rich Jordan are excited about the arrival of their adopted twin sons, Joey and Patrick, but they notice early on that Joey seems to drink excessively and then projectile vomits. By age two he is up all night demanding fluids and stops growing.
Parents Ed and Jane try to figure out why their son, Alex, is so unsteady on his feet, and why he has recurring sinus infections. A 31-year-old woman begins gaining weight and complaining of oily skin, hair loss, body cramps, and irritable bowel syndrome.
Natalie and Steve Bonfig are overjoyed after their second daughter Nicole is born. However, their worst fears are realized when they discover that Nicole is not only dealing with a serious heart condition, but has also stopped growing and gaining weight.
Soon after Maia Cooper is born she falls critically ill from whooping cough. Months after recovering from this illness her parents notice something troubling - Maia's hair appears abnormally brittle and she is slow in reaching developmental milestones.
Since childhood, Scott Gober battled an array of symptoms - severe joint pain, strange rashes, and an inability to sweat. First diagnosed with juvenile rheumatoid arthritis, his pain continued for years and doctors are still searching for the cause.
Roman Magana was just a baby when his parents noticed that his head was constantly tilting to one side. To make matters worse, his eye rolls back into his head when he looks up. Could both of these peculiar symptoms stem from the same condition?
Jackie Spar is an outgoing, active teenager who is full of promise until mysterious pains take over her entire body. The joint problems become so bad that Jackie must drop out of high school. Will doctors find out what is causing her malady in time?
A man in his late 30s experiences a constant, painful burning sensation in his chest, making breathing difficult, but an initial trip to the ER reveals nothing.
A person with Tourette's syndrome who endures thousands of violent tics a day; a father and son whose legs face backward. Also: sleep-eating; a parasitic twin; a teenage hunchback; Williams syndrome.
Jessica is a healthy teenager living with her parents in suburban New York. At the start of her freshman year in high school, she has bizarre episodes where she sleeps for 10 days straight. Doctor are baffled when her EEGs, EKGs, and MRIs appear normal.
A doctor administers surgery to identify and remove a young women's tumor, but finds something no one had noticed before. An avid marathon runner experiences escalating and unexplainable fatigue. His doctor tries to find out why.
Meredith Estes has baffling symptoms that can't be explained until she undergoes a risky left temporal craniotomy. Doug Posluszny can't explain his physical deterioration until an old acquaintance leads him to a physician who may have an answer.
16 year old Jennifer Fagenson takes aspirin to help alleviate altitude sickness, but ends up being rushed to the hospital.. In 1998, Joyce Gonzales feels sharp, needlelike pain shooting up her left arm. Within weeks the pain mysteriously spreads.
JoAnn Citrone's and her husband decide to start a family after enduring three long years of negative pregnancy tests. A man appears to suffer an embolism but the source of these life-threatening blood clots and how he survives stumps doctors.
3 month old Collin Campbell experiences sinus infections, chest congestion, and labored breathing. 42 yr old Laura McCann begins having stomach problems and diarrhea; after Quettia Davis steps on a crochet hook strange things begin to happen to her body.
Ashley's illness began with chronic diarrhea as an infant, and branched out to such diverse symptoms as ADHD and cataracts. Nissa, an ER nurse, took sick with the flu and was diagnosed with Lymphoma before swelling in her hands gave her illness away
Brenda and Jake are thrilled when Brenda gives birth to their first child, a baby girl, Isabel, who is diagnosed with jaundice. Over the next couple of days, Isabel stops eating, becomes more lethargic and turns an alarming grey color.
At birth Zachary seems perfect and healthy but as time progresses he misses his developmental milestones; twenty-two year old Danielle Mezzanotte has hardly been sick a day in her life, but then one day, everything changes when she becomes violently ill.
Jane Strauss experiences perpetual stomach pains and non-stop diarrhea which doctors attribute to IBS; LaShaun Davis is pregnant with her first child when she develops extreme fatigue, a lingering cold and severe night sweats.
Pat is extremely fatigued and can barely stay awake during the day. Oddest of all, she's craving pickles. Doctor visits reveal nothing and Pat lives with her condition until her heart almost stops. Will she learn why before her heart stops for good?
Rachel joyfully learns she is pregnant; then she begins to experience stomach pains and excruciating headaches. Jennifer experiences inflammation in her eyes, then develops pain and stiffness in her elbow, knees and thumbs.
Christina and Jason Wells are thrilled to find out she is pregnant then doctors see something on an ultrasound that worries them; Bruce Kemlitz was a high school biology teacher for over 25 years when, out of the blue, a bizarre symptom appears.
An aspiring actress awakens to an excruciating pain on the right side of her face. Bill experiences nausea and strange tingling in his legs. After several doctor visits and MRI test see how these two different cases reveal paralysis.
Trisha and David Kielb are thrilled when Trisha becomes pregnant with their first child, but their joy is short-lived when the baby is born without a heartbeat. Tracy Killarney leads a happy, busy life when suddenly she experiences excruciating headaches.
Dara Handel suffers from shortness of breath, chest and joint pain, extreme fatigue and a terrible cough, but doctors are baffled why; six-year old Erin Walsh is a playful, energetic kindergartner, until one November evening, when strange symptoms appear.
A baby boy has bouts of vomiting and diarrhea from the day of his birth; a young woman experiences blackouts after she hits puberty.
A 20-year-old college student named Mary Ann Piazza has been happy with her job as a babysitter and college life until she develops an unusual cough. It seems to be from minor ailments, but the cough proves to be incredibly persistent, and she becomes fatigued. Worse, Mary Annalso deals with shortness of breath, wheezing, constant weight loss, night sweats, and itchy skin.
Kirsten was overweight as a child. When she tried the slightest physical exertion, she would experience dizziness and shortness of breath. Dr. Robyn Barst, a leading specialist would finally reveal Kirsten's Diagnosis.
A baby has a genetic quirk that causes her lungs to have insufficient internal lubrication. Also shows the frustrations of a woman whose headaches are crippling. It was discovered that a flaw in her heart was causing stroke with the headaches.
Dan Hammond, a father of six-year-old triplets, has been healthy when suddenly, he discovers a strange lump on his tailbone. He thinks surgery should've taken care of the problem, but later on, Dan deals with painful, swollen legs; insomnia; a sudden bout of vomiting; a bright pink spot on his neck; a skyrocketing fever; and vision problems, especially in his right eye.
Heather and Todd brought their baby, Gaby home from the hospital. But right away, Gaby was having more health problems than most babies. First, a strange rash appeared. Then, Gaby started to suffer from frequent fevers, and ear and sinus infections.
Linda has been battling an astonishing array of ailments for over fifty years. While she continues to visit doctor after doctor searching for answers, no one can pinpoint exactly what's causing the random symptoms she experiences on a daily basis.
Amanda Coveler and her husband try to have a child, but they're faced with challenges as Amanda suffers from back-to-back miscarriages before conceiving successfully. Soon after giving birth, Amanda's life takes a turn for the worse.
A very active 41-year-old bodybuilder realizes that a strange lump has grown in her jaw while training for a competition; a boy has infrequent bowel movements.
A woman suffers dizziness following a family vacation; a patient is examined concerning severe stomach pain and swollen hands and arms.
A baby is examined after the whites of her eyes turn blue and her forehead bulges; a teen swimmer seeks help concerning deep pains in her hands.
A young woman experiences fainting spells in the aftermath of a car accident; an 11-year-old suffers a terrible headache.
A young student begins to suffer from paralyzing pain in his back; a couple adopts a girl and they find a huge and swollen lump on her shoulder.
An 18-month-old baby suddenly starts screaming one afternoon in the pool; a mother of two children begins to suffer a series of very debilitating headaches.
Rachele Lacount and Mike West are delighted that their baby has started to walk and talk, but suddenly they realize that something is wrong with his right eye.
Parents notice their 7-month-old son has troubling physical impairments; a woman travelling the world starts experiencing unusual back pain and tingling in her feet.
Diane and Howard have a baby boy with a mystery illness. Eventually, another doctor sees the newborn and diagnoses a rare and fatal disease, seen less than 100 times.
Holly is overjoyed at the birth of her second baby, Hannah Hannum, but soon realizes that she has Down syndrome; Carly and Nathan have just gotten married, when Carly falls extremely ill with strong nausea.
Doctors try to understand diseases that are often misdiagnosed, including a case of a newborn who has a cleft in the chest and another who shows very worrying symptoms.
Amanda Nixon has always struggled with the problems that come with having large breasts. At the age of 27, she has breast reduction surgery, but in the months afterward, she notices strange symptoms.
Todd and Julie are living the dream in Portland, OR with great jobs and two vibrant kids. One day their youngest, two-year-old Brooke, complains her right hip is hurting. They think she's just bumped it and wait for the pain to go away. But it doesn't...
Ever since she was born, young Claire Mantey has had a strange birthmark and swelling on the left side of her face. It didn't seem so serious at first, but the swelling and discoloration persist. Claire gets many ear infections, pain in the left side of her face, and eventually, fibrous displasia that spreads from her left jawbone to some of her other bones.
Kristin Gunther begins to suffer from great anxiety, confusion, and seizure-like movements. At first, doctors believe she simply has a viral form of meningitis, but after Kristin returns home, she becomes extremely anxious and delusional.
For years, Mary has had a problem with constant belching; now having difficulty breathing, she is seen by Gastroenterologist Dr Chey, who discovers something he has never seen before.
Jeff and Dina fear for their child when they discover that he does not cry when he is in pain; a woman in her thirties suffers inexplicable seizures.
When thirteen year old Nicole Beavers starts to slowly loose her hair, no one takes much notice, until the entire right side of her face begins to literally cave in.
When Samantha Lazazzaro was born, she had cataracts, or clouding of her eyes. She had surgery to correct it, but now, she has severe developmental delays, stunted growth, and tremors in her body. Her younger brother, Jake, has been born with the same symptoms, despite all prenatal testing coming back negative.
Diane may loose her legs or accept something even worse. The doctor thought it was a hematoma, but he realized he was wrong when Diane saw a new series of mysterious spots growing along her legs.
Walt has always been in good health until one day he suddenly faints; when he arrives at hospital, his blood pressure is very low and he has gained 100lbs of weight in water.
For the first few years of his life, a child's parents could barely get him to eat, but by the time he turns 12, he's gaining weight at a terrifying rate and eating everything he can get his hands on.
A girl had strange rush and blisters that started to grow on her arms and legs. Something that the doctors have never seen before.
Holly experiences horrifying pain that coincides with her menstrual cycle, will this threaten her chances for having children? Then Tina is struggling to keep up in school. Life gets worse when disfiguring growths start to form all over her body.
When the normally active Carole Battle falls violently on the floor, her family doesn't know that this is just the beginning of a deteriorating process. Sonya and Sherwood are delighted with their second daughter, but they begin to worry when the baby does not stop crying.
June goes in for a mammogram. Hours later, she loses a breast and is fighting for her life. Baby Brianna cries constantly and vomits every time she is fed. Weeks later, she begins having uncontrollable seizures as her parents struggle to find the cause.
When twelve-year-old Sammy and his family move to a new home, he develops bizarre habits, such as walking with his eyes closed and hands out front, refusing to sleep in his bed.
Jessica Blaszczak has been in perfect health, until she starts feeling unusually fatigued. She starts getting chills, spiking fevers, headaches, night sweats, nausea, muscle aches, and general weakness. And after Jake starts a military training program he finds hundreds of painful, fatty lumps appearing on his body.
Since she was born, young Julia Smith has had bruises all over her body. Doctors think the bruises aren't serious, but eventually, Julia bleeds profusely, just because of a cut on her face from her fingernail.
Karen has a pouch that collects her body's waste. Then, at the age of 48, she receives a phone call from someone who suggests she is suffering from a rare, and fatal, disease.
Lonnie White suddenly develops strange, painful bumps on his head, face, armpits, and then groin area that ooze.
A 3 year old's unexplained vaginal bleeding send her parents searching for answers to help their baby girl. And, a college freshman plagued by debilitating cramps is unable to hold her food down and drops down to just 72lbs.
A terrified mother rushes her 1 year old to the hospital when she suddenly looses the ability to walk or stand. And, an avid runner tries to sleep off a strange numbness in his foot, but he awakes to find the sensation spreading throughout his body.
Jeanne Nollman fails to hit puberty, so it seems that she is just a late bloomer. Her doctor tells her that her ovaries are underdeveloped and can become cancerous when actually, he has been hiding the fact that her gonads haven't developed at all into ovaries.
Young Adrian Martinez has always had a pinkish birthmark on his leg and has learned to deal with it. But when he is twelve years old, he develops hotness, unusual swelling, and pain in his right leg. His leg grows so much that after he starts high school, it weighs about one hundred and fifty pounds and it limits his ability to walk.
An older woman named Liana suffers from excruciating pain in her sinuses and blindness in her left eye. And a young single mother named Robin deals with breathing difficulties, coughing, fatigue, and body aches.
Ever since he was seven years old, Matt Horick has been dealing with strange symptoms relating to his skeletal system. He has had abnormal-looking toes, pain in his hips. And a two-year-old girl named Haven Fowler gains weight at an alarming rate, has hallucinations at night, eats while sleepwalking, goes into a seizure, and temporarily stops breathing.
Since her late teens, Tanya Angus has had a headache; a crackling sound in her head; an usual growth spurt; pain in her hands, feet, and back; and even an enlargement of her face. And since he was a toddler, Kody Burns has been coughing and having difficulties breathing. He appears to have asthma that went away when he was twelve, but he begins to cough up blood and strange white tissue at the age of sixteen.
Young Kylie Monica was born with a low birth weight, a cleft palate, a deformed thumb, and breathing difficulties And seventeen-year-old star athlete Michael Iniguez suddenly develops a sore, swollen throat, spiking fevers, chills, night sweats, and swollen feet. Soon, his kidneys begin to fail, and he goes into septic shock.
Since he was born, Ricky Getch's parents have been troubled by him being unusually small for his age and low appetite. And Noel Valero, an active father of two, suddenly blinks his eyes more frequently than usual, has unusual neck spasms, paralysis of his right triceps, and back pain that occurs in his entire back.
A 14-year-old develops a rash that leaves her fighting for her life; a young father's body begins to shut down.
Harry's body starts to undergo a mysterious transformation. Sadie finds herself on the brink of starvation after her doctor dismisses her complaints.
A girl is born with shocking deformities; a college student suffers from fluid around his heart and lungs.
Tammy Bangs has been a healthy 25-year-old woman, until she starts feeling extremely fatigued and achy, and things get really serious when Tammy cannot urinate at all and gets tingling sensations in her lower body that leads to paralysis. And a 43-year-old mother of two named Nadine Miller suddenly has trouble seeing and reading and eventually begins to have frightening hallucinations.
Young Payton Rule has trouble walking and using her hands from her weak muscles. Initially, she simply appears to be a late bloomer with hypotonia, but Payton doesn't improve. And Travis Walker has been a happy, active man, until he discovers a bump near his left index finger that grows to a big, red lump. This leads to Travis becoming lethargic and dehydrated with a fever and hypotension.
Doctors are baffled by a woman's mysterious respiratory problem.