After Bright Eyes was unable to be adopted at Adoption Day, a mysterious man by the name of Sam Quintin arrives at Holly's puppy pound and views her as a star. but unknown to the Gang, Quentin is a Con Artist!
The Pound Puppies tell their story of how Holly became the owner of a puppy pound and how they came face-to-face with the villainous Katrina Stoneheart for the very first time.
The Pound Puppies and Holly meet Buster, a puppy who is "a walking natural disaster". They are later invited to the Bellveshires' mansion in hopes of saving the pound from Katrina Stoneheart's latest dastardly plot.
The Pound Puppies rescue a pregnant dog from a severe snowstorm. However, when the power gets knocked out, it's up to Cooler, Howler, and Whopper to find a nearby veterinarian while the girls tend to the soon-to-be mother.
After wishing upon a star, The Pound Puppies meet an oddball fairy dog mother named Zazu, in hopes of helping Holly win the heart of a young boy named Mervin.
When Whopper's uncle JR comes for a visit, the Pound Puppies and Holly, Desperate to get Money to acquire Dog Food, disguise themselves as a wealthy family in order to impress him. However, Uncle JR has a secret of his own.
Someone or something has been stealing the puppies' items: Cooler's blanket, Nose Marie's necklace, Bright Eyes' doll and Whopper's squeak toy...
While in pursuit of rescuing Whopper from the evil Captain Slaughter, the Pound Puppies and Holly meet a trio of strange cats who wanted Captain Slaughter to capture them. But why?
After Bright Eyes is kidnapped by Clawfinger's two foreign spies, the other Pound Puppies, along with Pupnick, a friendly puppy from Mongrelia, go on an adventure to save Bright Eyes, James Bond style.
Cooler meets his long-lost girlfriend, Penelope, but is still angry whenever her name is mentioned. It all had something to do with Captain Slaughter and the once-existed town of Wagga Wagga.
A trio of Marx brothers-esque dogs called the Three Wise Guys arrive at the Pound in search of the Star Pup, a dog destined to defeat Captain Slaughter. The Star Pup is easily identified by a star-shaped birthmark. But when Nose Marie is suddenly idenified as the Star Pup by the mark on her neck, she is celebrated. But does she have the knowhow to beat the captain?
Holly and the puppies lose the pound after Katrina hid overdue bills. With no home for the puppies, it’s up to the help of Zazu to make Katrina reconsider re-opening the pound.
When the Terrible Terrier haunts Holly's Puppy Pound, the Pound Puppies turn to Biff Barker, a famous dog actor from a well-known TV series, "Ghost Hounders", for help.
Whopper learns that not all shots are painful.
Bright Eyes saves an injured baby bird from Catgut.
The Pound Puppies meet a puppy whose tail can't wag.
Whopper becomes in charge while Cooler and Nose Marie are gone.
The Pound Puppies are in for a surprise after a dirty dog becomes clean.
The Pound Puppies embark on a dangerous adventure to return a lost puppy to his owners.
The Pound Puppies meet Parents-to-Be Lucy and Rusty, so, Whopper and Bright Eyes want to know where Puppies come from.
The Pound Puppies try to figure out a way to stop Lucy and Rusty's pups from fighting.
The Pound Puppies meet a puppy named Buddy, who has an imaginary friend named "Bob".
A lost kid named Jerry wants stay with the Pound Puppies, but the Pound Puppies want to find Jerry a new home, as Jerry said that he wants to be adopted.
Nose Marie rescues a Small-as-a-Mouse puppy from Catgut and has grown attached to him, and Yes. He becomes a Giant.
Bright Eyes meets a group of tough dogs and does their dirty work, making the public mistake her as a wanted criminal.
Whopper must conquer his fear of the dark after numerous nightmares.
A girl runs away from home after mom refuses to let her adopt a puppy.
The Pound Puppies invent a holiday dedicated to Nose Marie.
The Pound Puppies journey to the arctic and a high-speed chase through the snow ensues thanks to Katrina Stoneheart.
The Pound Puppies meets Sparky, a retriever who wants to be a fire-dog, but Whopper tries to change Sparky's Personality.
Whopper helps a puppy snap out of her persistent boredom.
The Pound Puppies enters Bright Eyes at a Pet Talent Show.
Whopper befriends a young caterpillar.
In the only musical episode ever produced, The Pound Puppies must reform a group of dogs who eat nothing but junk-food every day.
After Whopper and Bright Eyes accidentally break a TV, Holly reads them a story about a puppy who lies, (Whopper) an evil queen, (Katrina) a magical land, and Peter Pup (Cooler) himself, in which the pups participate in an adventure of their own.
The series concludes as Cooler is kidnapped by Katrina, taken to a dog pound somewhere in the USA, and meets a stubborn dog who refuses to be adopted while his friends try desperately to find him.
On a magical artifact called the Bone of Scone, that gives "Puppy Power" to the Pound Puppies and Pound Purries. However, a villain named Marvin McNasty plans to take it and use it for world domination. Without the Bone of Scone, humans will not understand what the animals are saying and, if it is broken, Puppy Power will forever be lost.
A female dog from a wealthy aristocratic family named Violet Vanderfeller is being pursued by dognappers when she is picked up and taken to the city pound. There, she meets the gang and discovers their mission to find homes for themselves. The film plot centers on Violet (whom Cooler insists on referring to as "Sam") attempting to reunite with her family, ultimately succeeding. Two other dogs appeared in the special. They were the upper-class snob Barkerville and the garbage-can-digging Scrounger.