Bill Burr / Jack White

Jack White performs a medley of "Ball and Biscuit", "Don't Hurt Yourself" and Blind Willie Johnson's "Jesus is Coming Soon" for his first set and "Lazaretto" for his second. Jim Carrey and Maya Rudolph appear as Joe Biden and Kamala Harris, respectively, in the cold open; as Biden, Carrey also appears as Jeff Goldblum and Seth Brundle, Goldblum's character from the 1986 film The Fly. Jason Momoa appears in the pre-recorded "Enough is Enough" sketch. The episode pays multiple tributes to Eddie Van Halen, who had died earlier in the week: footage of him performing with the Robert Cray Band from season 12 is shown before the goodnights, White uses a guitar designed especially for him by Van Halen during his performance of "Lazaretto", and Burr wears a Van Halen shirt during the goodnights.