Peter Parker is on assignment for J. Jonah Jameson, investigating mystery lights outside of the New York City limits for possible Daily Bugle pictures, when a rock avalanche forces his car off of a road and onto a tree part-way down a cliff. Peter changes to Spiderman and uses webbing to gently bring his car to a landing at the base of the cliff, where he notices light emanating from an opening in the rock, revealing a gadget-filled cave wherein the multi-mechanical-armed Doctor Octopus is scheming to trigger a series of underground explosions in Manhattan. Octopus surprises Spidey by dropping an entangling chain around the super-hero, then confines Spidey behind a descending set of jail cell bars. When Peter is overdue at the Bugle, Betty Brant drives her car to the same location and is also captured by Octopus. With his back turned from Spidey and Brant, Octopus initiates his diabolical plan as proof of his power to devastate New York. Spidey sprays his webbing into the jail cell locks that imprison himself and Betty, the webbing serves as a key, and Betty is free to run for help, while Spidey fights Octopus, shooting webbing at Octopus' glasses and blinding the villain so that he can be webbed to a wooden beam in the cave. The police, summoned to the scene by Betty, arrest Octopus, and Betty is reunited with Peter, who tells to her that he has been looking for a mechanic to repair his car.
A group of giant ice creatures situate in New York Harbor in their damaged, diamond-like spaceship and abduct Dr. Smartyr, a noted scientist. Spidey boards the alien space vessel, passes through a maze of perilous, icy tunnels, and finds the aliens' control room, where Smartyr, an expert in propulsion, is helping the creatures, friendly Plutonians who were forced to land on Earth for repairs to their spaceship. With his new invention, a space warp control device, Smartyr assists the Plutonians to launch their spacecraft out of New York Harbor, leave Earth, and return to Pluto. But neither Smartyr nor Spidey will tell anyone about their encounter with aliens.
Reports of a lizard-man terrorizing the Everglades bring Spiderman to Florida, where he finds that a Doctor Conner, by testing a swamp fever serum upon himself, has changed into an intelligent lizard. The lizard that Conner has become intends to use a beaker containing the serum, which it confiscates from Conner's laboratory, to convert alligators into reptiles that share its level of intelligence, to follow it in conquest of humanity. Spidey applies his knowledge of science to conceive an antidote to the serum and confronts Conner's lizard alter-ego at an old, Spanish fort, webbing the bipedal reptile before it can release the serum into the Florida swamps, and forcing it to drink the antidote that changes it back to Conner, who does not remember any of his acts as the Lizard but is immensely grateful for Spidey's help, as are his wife and son.
Electro, a villain capable of emitting energy bolts from his hands, robs J. Jonah Jameson's wall safe as the beginning of a crime wave which is investigated by Spiderman and ends in a confrontation with Electro in an amusement park. By his reflections, Spidey draws Electro's fire in a hall of mirrors, then startles Electro with an electricity-negating, asbestos-laced webbing dropped from above onto the villain. Spidey gives the webbed Electro to Jameson for the New York Police Department (the NYPD) to apprehend.
Spider-man has robbed a bank! But Peter Parker doesn't remember robbing a bank. He figures it must be an impostor. Meanwhile, J Jonah Jameson has being recieving calls from a mysterious Mysterio. He claims that he could defeat Spider-man and bets with Jonah on it. Jonah puts Mysterio's challenge on the front page of the Daily Bugle though Spider-man is in trouble with the law. Spider-man arrives at Mysterio's meeting place (a bridge) and they battle there. Mysterio hits Spider-man into the water and Mysterio thinks he won! When really Spidey survived and swam underwater. Peter Parker was in Jonah's office when Mysterio came, wanting his money. Jonah says they haven't proved Spider-man's dead but will only give half of it. As Mysterio exits the office, Peter puts a Spider-tracter on his cloak. Spidey follows him to a TV studio where he meets him. They battle there and Spider-man managed to make Mysterio confess that the Spider-man that robbed the bank is fake and reveal that he
The Vulture, a man-bird villain, possesses an electronic device inducing huge flocks of birds to join him in attacking New York City. Unless the mayor bestows to the Vulture 2 million dollars, the Vulture promises to continue his reign of terror from the sky. Scientifically astute and resourceful Spidey drops a device that disrupts the bird-controlling transmissions, onto the Vulture's head, and provokes the bird-man into giving to the birds the attack signal, which causes the confused birds to attack the Vulture and force the flying criminal to flee, without the 2 million dollars that he tried to extort.
Jameson employs a brilliant scientist named Henry Smythe in an effort to catch and unmask Spiderman by means of a relentless robot that speaks in Jameson's voice and has an image of Jameson's face in its head. After a lengthy chase that leaves Spidey fatigued, short of breath, and easily captured by the robot, Spidey uses the suction power of his fingers to open the lid to the robot's control centre and removes the spider-detecting circuitry that initially put the robot onto his trail, and when Jameson and Smythe arrive at the place of Spidey's apparent capture, Jameson removes the mask of what he thinks is Spiderman and finds a straw dummy in a Spiderman costume, in the arms of a non- functional robot. The frustrated Jameson never wants to see Smythe or Smythe's robot ever again.
Jameson's latest Spiderman-catching scheme involves a genetically mutated humanoid scorpion created by a scientist named Dr. Stillwell, but the Scorpion's allegiances are fickle, the monster soon declares Jameson as his number one enemy, and Spiderman must rescue his newspaper-publishing nemesis from the beast's murderous clutches. Fortunately, the Scorpion is vulnerable to Spidey's webbing, and Spidey captures the Scorpion for police capture, not once but twice, after the Scorpion escapes prison and attempts again to kill Jameson.
The Sandman, a villain capable of dissolving into a moving heap of sand, slips under the defense mechanisms at a police-guarded exhibit and robs the Goliath Diamond. When the Sandman demands a two million dollar ransom for returning the diamond and specifies a rock quarry as a money-for- diamond transfer point, Spidey arrives there with the money in a suitcase and stickily webs the bottom of the suitcase to a rock, from which the Sandman is thus unable to lift the suitcase. In the ensuing battle, Spidey's makeshift web-shield deflects the boulders falling upon him from a bulldozer controlled by the Sandman. Spidey then spins his webbing into a huge slingshot that deflects the bulldozer's wrecking ball back at the bulldozer, throwing the Sandman from the vehicle and into a vat of water, where the Sandman becomes soggy and weak and drops the diamond. Spidey gives diamond and soggy Sandman to the police.
A ghoulish villain, the Green Goblin, plans to conjure demons of the spirit world to do his bidding and to this end uses J. Jonah Jameson as a hypnotized medium to the evil realm. Spidey trails the Goblin and Jameson to a cemetery to battle the green-skinned ghoul. He webs and tips the Goblin's cauldron from which the evil spirits are emerging. The spirits disappear as the cauldron's liquid contents seep into the ground, and Spidey webs the Goblin. The recuperating Jameson has no memory of any of these events.
Electro exploits an electrical storm to recharge his energy powers and escape jail. He hijacks the New York City power station and intends to blackmail the city into accepting his demand of total rule. Spiderman confronts Electro first at the power station and then in Times Square. In Times Square, Spidey spins his special, electricity-resistant webbing formula to form a large net, then webs a personal shield to deflect one of Electro's bolts so that the bolt blasts a hole through a wooden ledge. Electro, walking confidently toward Spidey, falls through the hole and into the net, where Spidey's electricity-resistant webbing traps Electro for police to recapture him.
A convict named Red Dog Melvin escapes jail and is granted asylum at Parafino's Wax Museum, where Red Dog is put in suspended animation and coated with wax by fanatical wax artist Parafino, whose advertised exhibit of Red Dog lures Spidey to the museum for a nighttime visit. Planning to turn the web-swinger into a wax-covered exhibit, Parafino throws an ultra-sticky wax at Spidey's hands and feet, pinning Spidey on a pedestal. Betty Brant arrives at the museum in search for Peter, who told to her that he was going to investigate the museum, and Parafino captures her too. However, Spidey uses heat to his advantage, first from a lamp above his pedestal to melt the wax on his hands (thus enabling him to pull his feet free from the wax bonding them to the pedestal), then by hitting with his webbing a wax temperature control that increases heat to cause Parafino to melt! The real Parafino emerges to continue the work of his melted wax self-image, but Red Dog reanimates and grabs Parafino, and Spidey webs them both.
Sick with a cold, Spiderman must battle the Rhino, a powerful, horned villain capable of ramming through trains, trucks, and submarines. Though Peter's Aunt May forbids her ailing nephew to procure pictures for Jameson of the Rhino's wrath, Peter leaves his bed to become Spiderman each time that a component to a top-secret military weapon is due to arrive in New York City, because the Rhino wants the weapon and will stop at nothing to steal the components, three in total, coming to New York by train, airplane, and submarine. But the sneezing Spidey is unable to stop the Rhino from snatching the components. Finally, as the Rhino is assembling the weapon from the three heisted components, Spidey obtains a can of pepper from Aunt May's cupboard, finds the Rhino's hideout, a cave at the New York City Zoo, and webs the can of pepper onto the Rhino's horn, which punctures the can, and pepper drops in the Rhino's face so that the Rhino now too has a sneezing handicap. An avalanche of mud falls upon the Rhino, and Spidey bakes the mud with a heat ray to trap the horned criminal, then gains possession of the weapon to return it to the military. The Rhino is apprehended by the NYPD, and Peter confines himself to bed to allow Aunt May to fully treat his cold.
Australian hunter Harley Clivendon pretends to be secret admirer of J. Jonah Jameson and gives as a "token of (his) esteem" to the cantankerous newspaper publisher a weird, hypnotic idol, which entrances Jameson into robbing his own wall safe and placing the money inside of the idol for Clivendon's aborigine helper to collect. When Spidey discovers Clivendon's scheme, Clivendon throws a boomerang to strike Spidey unconscious and binds Spidey beneath an elevator carriage to be crushed when the carriage reaches ground level, but Spidey breaks his bindings to escape from the descending carriage and confronts Clivendon. After dodging the spears hurled and bullets fired at him by Clivendon, Spidey throws the advancing aborigine at Clivendon and webs them both for police capture- and Jameson has his money back.
The Phantom, a faceless, hooded villain, orchestrates a trio of female robots, all with reducing rays, to steal merchandise from Bennet's Department Store. Intending to catch the Phantom, Spiderman trails the beautiful robots and a stolen doll house containing the shrunken items. He is captured by one of the robots toting a laser gun and brought to the Phantom's headquarters, where the robots restore the merchandise to full size. Spidey springs into action, deactivates the robots, and webs the Phantom. The police return the stolen items to Bennet's.
Dr. Magneto, a scientist with a gun capable of magnetizing and demagnetizing various objects, plans revenge upon the world for ridiculing his theories. He causes a rail bridge to collapse, then lifts and drops a statue from high altitude, but Spidey arrives on the scene and prevents Magneto's schemes from causing loss of life. Then, Spidey confronts Magneto in a museum and, with a dense, anti-magnetic webbing, smashes Magneto's magnetizing gun. He then webs Magneto in the usual manner and places the disgraced scientist on a pedestal in the museum for police to apprehend.
Spiderman discovers that the visiting Prime Minister of Rutania is an imposter and must by himself battle the identity-usurper, whose cane is a veritable arsenal! The phoney Prime Minister, under the pretense of obtaining a multi-million dollar loan to aid the impoverished people of his country, has duped the American government and J. Jonah Jameson into bestowing upon him a fortune in gold bullion. While battling the imposter Prime Minister aboard an airplane, Spidey uses his webbing to knock the cane out of the imposter's hand and pin it to the fuselage's wall. He webs the imposter and, with armed guards as witnesses, removes the imposter's make-up to reveal actor Charles Cameo. Spidey also releases the real Prime Minister alive from a trunk aboard the airplane.
Under the guidance of Dr. Noah Boddy, the Green Goblin, Electro, and the Vulture join forces for revenge on Spiderman. In a confrontation with Noah Boddy's three stooges, Spidey practices ventriloquism to cause each of the three miscreants to think that he is being insulted by the others, and the excitable trio of villains begin fighting each other.
On his first night at work at the Daily Bugle, Peter overhears talk of a fake medicine racket engineered by a rotund mobster called the Kingpin, whose thugs have a laboratory somewhere where they produce cheap, imitation pharmaceuticals, which are then peddled at gunpoint to druggists, who are subsequently frightened into selling the fake medicine and not signing a complaint for the police.
A twisted radiation specialist gains illicit dominion over Manhattan's new and only nuclear power plant and uses a special ray to lift Manhattan into the clouds, and unless he is amply paid, granted amnesty from arrest, and permitted to build his own nuclear reactor, he will deactivate the ray and plunge the island by force of gravity back down to Earth.
Investigating the disappearance of banks (which have been mechanically submerged to deep inside the Earth), Spidey finds a hole that leads to a maze of underground tunnels, through which Spidey undertakes a perilous journey in search of the lost occupants of the submerged banks, and he comes upon a bizarre city populated by group of Molemen led by a maniac intent on conquest of the ""surface people"", some of whom- the occupants of the banks-the Molemen are holding prisoner.
A baseball diamond and the spherical, baseball-sized Optimo Diamond at the Cosmopolitan Museum are connected in this episode as Peter, about to be the star pitcher in a collegiate baseball game, is obliged to don his Spidey-suit once to stop a rampaging ape at the New York City Zoo and again to thwart men in ape disguise at the museum from stealing the Optimo.
Mugs Riley, evidently escaped from prison, has duped the Molemen into following him again, even though they angrily deposed him in ""Menace From the Bottom of the World"", and arranges for Spiderman to be attached to a building so that the web-swinger will be brought underground along with the building, to face the revenge of Mugs Riley.
In ancient Egypt, one of the most aggressive of evil magicians, Kotep, the Scarlet Sorcerer, is defeated in battle with an opponent, and his own demons strike him with a cursing ball of fire that puts him in suspended animation, his mummified remains lasting through the passing centuries and becoming an exhibit at a New York university and the object of a professor's obsession.
A giant plant escapes from storage in a house belonging to Prof. Smithers, a missing scientist. Spidey goes through a portal (located in the scientist's home) to prehistoric times to find some defense against the plant and meets Smithers, who tells to him that two radium gems in an idol in a nearby city, if ingested by the plant in New York, will disintegrate it.
Pardo is a sorcerer with the ability to transform himself into a giant cat with hypnotic eyes. He lures top New York City citizens and officials to a theatre with the promise of a spectacular show, then releases his feline alter-ego's power upon the hapless audience, intending to divest them of their wealth and sap the souls out of their bodies.
Peter is an exchange student in South America, flying in a charter airplane with a Latin American professor in the Andes mountains. The airplane encounters a violent storm and crashes in a jungle, and Peter changes to Spiderman to assist the professor and the airplane's two pilots in leaving the jungle and returning to civilization.
Spidey swings to Florida again to battle a walking, thinking lizard. This time, the lizard is not a transformed Dr. Conner, but a reptile whose intelligence has been augmented in an experiment by Conner gone awry, and who has kidnaped Conner and holds the ill-fated scientist as captive at a Spanish fort.
The weird Dr. Atlantian rises out of the ocean near New York City in his hive-like machine, which derives its power from Lunar motion. Atlantian represents the lost continent of Atlantis, which has developed an advanced technology in its centuries of undersea existence and now intends to conquer the surface world.
A remake of Season 2's ""Vine"", virtually identical in plot; the only difference is that instead of a giant plant threatening New York, the menace is a series of enormous, rolling pods that grow from boxes in a missing scientist's house. The scientist has used a time portal located in his house to journey into another dimension, and the rolling pods have come from that dimension, the Land of Crystal Creation.
A dying scientist from the destroyed planet Goth in the deceased galaxy of Kamosah must land his crippled spaceship on Earth and, before expiring, entrusts Spiderman with a tiny but encyclopedic library of information, including the secrets of a dimension of living thought, whose one-eyed, skeletal ruler, Infinata, wants this information destroyed.
Jameson orders Peter to fly in an airplane with Daily Bugle pilot Osa Olsen to the North Pole to locate a fallen meteor with bizarre antennae, but a thunder-snowstorm cripples Parker and Olsen's airplane, and it crashes in a wasteland populated by a tribe of savages, who have appropriated the meteor and are planning to drop it into a volcano as an offering to their fire god in return for warmth.