The show returns to normal service with a stellar line-up of guests, both in-studio and connecting remotely. Joining Graham are Dolly Parton, Rupert Everett, Lolly Adefope, Riz Ahmed, Sara Pascoe and musical guest Roisin Murphy, who performs her single Murphy's Law.
| Name | Type | Role | |
|---|---|---|---|
| Róisín Murphy | Musical Guest | ||
| Rupert Everett | Guest Star | ||
| Lolly Adefope | Guest Star | ||
| Riz Ahmed | Guest Star | ||
| Sara Pascoe | Guest Star | ||
| Dolly Parton | Guest Star |