Jonathan's guests this time are star of Grey’s Anatomy Patrick Dempsey, BRITs host Jack Whitehall, father-and-daughter duo Danny and Dani Dyer and music and chat from Self Esteem.
| Name | Type | Role | |
|---|---|---|---|
| Jonathan Ross | Writer | ||
| James Farmer | Writer | ||
| Annie McGrath | Writer | ||
| Self Esteem | Musical Guest | ||
| Jack Whitehall | Guest Star | ||
| Patrick Dempsey | Guest Star | ||
| Dani Dyer | Guest Star | ||
| Danny Dyer | Guest Star | ||
| Chris Howe | Director |