The Juno Awards of 2021, honouring Canadian music achievements, were presented on 6 June 2021, observing the 50th anniversary of these awards. The main ceremonies were televised on CBC.
| Name | Type | Role | |
|---|---|---|---|
| Julia Michaels | Musical Guest | ||
| Jessie Reyez | Musical Guest | ||
| Justin Bieber | Musical Guest | ||
| JP Saxe | Musical Guest |