The X-Men must unite to face a new threat.
| Name | Type | Role | |
|---|---|---|---|
| Anthony Sellitti | Writer | ||
| Beau DeMayo | Writer | ||
| Matthew Waterson | Guest Star | Overeager Journalist | |
| Morla Gorrondona | Guest Star | Empress Lilandra | |
| JP Karliak | Guest Star | Reverend Stryker | |
| Rama Vallury | Guest Star | Baron Zemo | |
| Jennifer Hale | Guest Star | Female Prime | |
| Rachel Kimsey | Guest Star | News Anchor / News Pundits / Computer Cube | |
| Travis Willingham | Guest Star | Sebastian Shaw | |
| Jeff Bennett | Guest Star | Ford | |
| Theo James | Guest Star | Bastion | |
| Ross Marquand | Guest Star | Latverian OZT Member | |
| Christine Uhebe | Guest Star | Nina Da Costa | |
| Eric Bauza | Guest Star | Mastermold / Prime Sentinels | |
| Kari Wahlgren | Guest Star | Rose | |
| Donna Jay Fulks | Guest Star | Bespectacled Teacher / Female Teacher | |
| Anjali Bhimani | Guest Star | Daria / News Anchor | |
| Christopher Britton | Guest Star | Mr. Sinister / American OZT Member | |
| Holly Chou | Guest Star | Chinese OZT Member | |
| Chase Conley | Director |