Yorick and Agent 355 search for Dr. Allison Mann in war-torn Boston. Back in D.C., Jennifer hides the truth about Yorick from her political rivals.
Yorick, Agent 355 and Dr. Mann hit a snag on their way to San Francisco. As the search for 355 heats up, Jennifer clashes with former cabinet secretary Regina Oliver, who has her eyes on the presidency. Hero is seduced by a charismatic leader, Roxanne, as Sam and Nora grapple with their place in a dangerous group of survivors.
Kimberly uncovers a secret. 355 and Allison reach an understanding. Yorick stumbles on a mysterious town where things are not what they seem.
Tensions at the PriceMax spiral out of control. Hero and Sam pass the point of no return. Nora uncovers dangerous secrets.