A trip to the lake goes horribly awry when a car runs over a squirrel. Little do the passengers know that when something gets run over on this road, it comes back to life. For revenge.
Simon goes looking for help but instead finds a cloud of demon skunk gas - and an ambush awaiting him inside.
Half a dozen cars lie empty in the middle of the road. The remnants of a bloody massacre. Simon searches for survivors. But the only survivors have fur and an unquenchable thirst for blood.
Simon and the Ranger finally escape... or so they think. But when Simon wants to turn back to save his friends, the curse of the road rears its ugly head.
Day turns to night, and the creatures are hungry for dinner. Simon rushes back to save his friends before it's too late.
Simon and his friends battle dozens of bloodthirsty critters. In a final confrontation with the zombie squirrel, they discover the rule of the road.