Jon Arbuckle buys a second pet, a dog named Odie. However, Odie is then abducted and it is up to Jon's cat, Garfield, to find and rescue the canine.
Jon Arbuckle plans to propose to his girlfriend Dr. Liz Wilson, who is going on a business trip to London. Jon follows her to the United Kingdom as a surprise; After escaping from the kennel, Garfield (character) and Odie sneak into Jon's luggage and join him on the road trip. Garfield and Odie break out of the hotel room due to boredom, and subsequently get lost on the streets of London.