The story begins on a fog-bound moonlight night in a swamp; a wolf howls. The scene shifts to the nearby laboratory of Dr. Lorenzo Cameron (George Zucco), who draws blood from a caged wolf. Secured to a table is Dr. Cameron's simpleminded but strong gardener, Petro (Glenn Strange), who is to be the doctor's subject in an experiment. Cameron injects a serum made from a wolf's blood into the cooperative Petro, who loses consciousness, grows fur and fangs and awakens after he has turned into a wolfman.
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