俗語有云「人紅是非多」，四位「是非精」主持李佳芯(Ali)、黃心穎(Jacqueline)、梁嘉琪、麥美恩(Mayanne)卻因為經常「講是講非」而人氣急升。節目承接上輯，四人帶來更多「是非」回歸，並繼續貫徹寓學習於娛樂的風格，輕鬆破解日常生活中經常遇到的謬誤。 另外，她們還會邀請不同專家現身節目，藉著實地測試，逐一驗證各種眾說紛紜、似是而非的都市傳聞，根據專業理論作出分析講解。作為上輯節目的升級版，四人更會挑戰各種「大是大非」，每集邀請一位男嘉賓一同拆解身邊各項大型基建工程謎團，例如懸掛半空的昂坪纜車鋼纜到底是如何維修，深入地底六層的金鐘超級轉車站用上甚麼全新爆破技術興建等等。
| Season | From | To | Episodes |
|---|---|---|---|
| All Seasons | |||
| Specials | 0 | ||
| Season 1 | April 2013 | 55 | |
| Season 2 | 18 | ||
| Season 3 | 9 | ||
| Season 4 | 14 | ||
| Season 5 | May 2017 | 2 | |
| Season 6 | June 2018 | February 2019 | 22 |
| Season 7 | January 2020 | December 2020 | 26 |
| Unassigned Episodes | 3 |
| Season | From | To | Episodes |
|---|---|---|---|
| Unassigned Episodes | 149 |
| Season | From | To | Episodes |
|---|---|---|---|
| Season 1 | 0 | ||
| Unassigned Episodes | 149 |
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