College student Marian moves into the dormitory room where a young woman recently died and senses an alarming supernatural force as she reluctantly turns to the Others -- a small but diverse group of people dedicated to analyzing their extrasensory abilities -- who urge her to embrace her ""fearsome talent."" But she soon discovers that whatever gift of insight she possesses is both a blessing and a curse that puts her life in danger, forcing her to appeal to a famed medium, an empathic medical intern and a New Age ""sensitive"" among the Others.
While Elmer senses a dreadful dark force on the horizon, Satori tries to help the single mother whose young son has been missing for three years - and whose ethereal presence is suddenly felt by both women. Aware of the unknown power that opposes them, Elmer and the Others need Marian's supernatural gifts to counter the unseen evil that they believe is responsible for the boy's abduction.
A vain and egotistical man decides on laser surgery to correct his eyesight, but after the first operation begins to see horrific apparitions which threaten his sanity. Meanwhile, Marian puzzles over Albert's enigmatic past until she unwittingly begins to share his nightly vision of the TET Offensive maneuver that cost his eyesight.
Just as the Others board a plane to Sedona, Arizona for a psychic conference, they learn that an inquisitive Miles purposely booked them on the same flight path previously occupied by an aircraft that recently crashed, and the harrowing activities they witness are thought to be somehow linked to parts salvaged from the wreckage -- and recycled onto their jetliner. As the Others react to the sight of tormented faces pressed against the outside windows and through the cabin walls, Marian has a strange encounter with the captain of the doomed crew, who has an urgent message only Miles can decipher.
The group helps a woman grieving for her child and husband killed in a car accident--a process complicated when they discover that the husband is not yet dead.
As an unsure Marian considers withdrawing from the Others, she moves into a new apartment that harbors a vague yet sinister force hiding in the wallpaper intent on scaring her enough to ignore her supernatural gift, but she is more concerned to learn that some of the Others appear to be stalking her. Meanwhile, Mark is tormented by the responsibility of his empathic abilities and can find relief only in the arms of Satori, but they are prevented from becoming physically intimate because proximity causes their environment to explode.
Marian thinks joining a sorority will help her regain some normalcy in her life -- until she learns one of the sisters is under psychic attack. She befriends troubled college coed Jenny, who is plagued by chronic panic attacks of horrifying visions from her childhood that become more physically forceful and threaten her bewildered Theta sorority sisters. Marian recruits the help of the Others, who suspect that the Theta house is haunted based on a murder on the same grounds long ago, but wise old Elmer deduces that something evil from the young woman's painful past is intruding with harmful intent. This turns out to be her imprisoned father, shot by Jenny as a child when he murdered her mother and now bent on revenge.
A restless Mark is disturbed by his continuing dreams where he falls in love with Mary Jane, a mysterious beautiful woman from 19th-century London who also sees Mark only in her dreams. Ignoring Elmer's stern advice to stop his dalliance or risk his own destruction, a sheepish Mark asks love struck Marian to help him channel through to his would-be lover. Then an Internet search by Miles reveals that Mary Jane Kelly was the last victim of Jack the Ripper.
On a stormy night, the seers are terrorized by the Rabisu, an ""entrance demon"" who invades Elmer's house and preys on their minds with the repeated question: ""What do you want?""
Elmer wrestles with his distant past as an American serviceman based in Britain during World War II whose special psychic gifts were employed even then to help doomed flyers ""get to the other side"" -- but there was one who refused to go, and his fate is now intertwined with that of a downed American pilot who is lost in the Iraqi desert. As time winds down before the pilot is captured, Elmer enlists the help of Marian to lock on to the pilot's position while the regretful old man confronts a spirit that might be lost forever -- and a very surprisingly other visitant.
A phony, cash-poor psychic calling himself ""Simeon Nye"" is frightened when his disastrous visions of his clients' futures begin to come true, so he seeks help from his more serious competition -- Satori -- who agrees to aid the bewildered man when she discovers he also inexplicably functions as a medium to her long-dead father (through their agreed-upon code word ""Kermit""). But Satori learns that the charlatan has unknowingly summoned an angry spirit -- the ghost of the real Simeon Nye -- and if she renders assistance in ridding him of it, she will lose the chance to satisfy her dream of communicating with her dad.
In the season (and series) finale, Elmer is mysteriously brought back from the dead, and as he recovers, he again senses the presence of entrance demons -- specifically the beckoning and beautiful woman who stalks him from the other side -- and fears for the ""Others"" when each one gains something highly desirable. The old man warns his friends not to be deceived by the false reality when Miles is offered a prestigious professorship, Marian finds a kindred spirit roommate, and Satori and Mark find they can embrace each other without fear.
When three emergency room patients die mysteriously all at once under his care, Mark clashes with his father, a hospital board member, over his contention that he saw several tiny snake-like creatures in the equipment -- but neither is unaware of the sinister force present that coincides with the arrival of a sickly elderly woman. Elmer, Marian and the rest of the ""Others"" rush to help Mark after he is struck down by a phantom illness, and they discover that the missing link might be the geriatric female patient who is deathly fearful of ""the Mora,"" fearsome monsters from Eastern European folklore. When they find talismanic fetishes under the beds of the deceased patients, the Others' suspicions focus on the Russian janitor, but he turns out to be attempting to ward off the evil. The old woman turns out to be a 110-year-old former ballet star who fled the Russian Revolution, leaving her infant son behind, and who is afraid to die until she learns what happened to her son; the Mora are,