When his niece Naomi, a college student, is reported missing, seasoned Forensic Psychology Alex Cross begins to investigate the young women who have vanished from the area. During his investigation, a young intern escapes her captor and her friendship with Alex helps him understand the mind of the killer.
Detective and psychologist Alex Cross teams with a disgraced Secret Service agent to find a senator's daughter abducted from an exclusive prep school.
Dr. Alex Cross (Tyler Perry) is a psychologist and police lieutenant who now lives in Detroit with his wife Maria (Carmen Ejogo) and their children. After learning Maria is pregnant, Cross considers accepting a job as an Federal Bureau of Investigation profiler. Meanwhile, a man (Matthew Fox) participates in an underground fighting match and seduces businesswoman Fan Yau (Stephanie Jacobsen). The man is invited to Yau's house, where he kills her.