A young man carrying a big basket that contains his extremely deformed, formerly conjoined twin brother seeks vengeance on the doctors who separated them against their will.
Having survived their fall at the end of the first film, Duane Bradley and his hideously deformed brother Belial are rescued from the hospital by an elderly woman named Ruth who, along with her beautiful granddaughter, are the caretakers of an extended family of similarly deformed individuals. When a snooping tabloid reporter and a sleazy photographer threaten to endanger the community's welfare, the two brothers join with the freaks to defend their privacy with a vengeance.
After crudely trying to sew his monstrous former conjoined twin Belial back on to his side at the end of the previous film, Duane Bradley is re-separated from Belial and put in a straitjacket and padded cell in Granny Ruth's haven for "unique (deformed) individuals". After several months of captivity Duane is released by Granny Ruth, who is preparing to take everyone on a road trip to the home of her ex-husband Doctor Hal Rockwell, who will help in giving birth to Belial's equally misshapen girlfriend Eve's babies; before leaving for the trip, Granny Ruth sternly tells Duane to stay away from Belial, who has stopped speaking to Duane telepathically after Duane's attempt to put them back together.