A woman discovers the newly resurrected, partially formed, body of her brother-in-law. She starts killing for him to revitalize his body so he can escape the demonic beings that are pursuing him after he escaped their sadistic underworld.
At some point in the past, British military officer, Elliott Spencer uses the Lemarchand's box, the doorway to the world of the Cenobite (Hellraiser), and becomes the Cenobite Pinhead.
The revelation of his own former humanity in ''Hellbound: Hellraiser II'' causes Pinhead (Hellraiser), a demon called a Cenobite (Hellraiser), to be split into two entities: his former self, World War I British Army Captain Elliot Spencer, and a manifestation of Spencer's Id, ego and super-ego, which takes on the form of Pinhead. While Spencer ends up in limbo, Pinhead is trapped, along with the Lemarchand's box, among the writhing figures and distorted faces etched into the surface of an intricately carved pillar — the Pillar of Souls.
In 2127, Dr. Paul Merchant, an engineer, seals himself in a room aboard The Minos, a space station that he designed. As armed guards attempt to break through the door, Merchant manipulates a robot into solving the Lemarchand's box, destroying the robot in the process. The guards break through the door and apprehend Merchant, who agrees to explain his motivations to their leader, Rimmer.
Joseph Thorne is a corrupt Denver police detective who regularly indulges in drug use and infidelity during the course of duty. At the scene of what appears to be a ritual murder, Thorne discovers a strange puzzle box, which he takes home in order to indulge his fascination with puzzles. After solving the box, Thorne begins to experience bizarre hallucinations, such as being seduced by a pair of mutilated women and being chased by a creature with no eyes or legs. Thorne also makes a connection between the murder and a killer known as "List of Hellraiser characters#Engineer," who is suspected of having kidnapped a child. Thorne goes in search of the Engineer, who in turn begins murdering Thorne's friends and associates, leaving behind one of the child's fingers at every crime scene.
Trevor Gooden (Dean Winters) survives a car accident that apparently killed his wife Kirsty Cotton-Gooden (Ashley Laurence) when their car plunged off a bridge into the river below. Trevor manages to escape with his life, but even though police divers find both car doors open there is no sign of Kirsty.
Reporter Amy Klein (Kari Wuhrer) is sent to Bucharest at the behest of her boss, Charles (Simon Kunz), to investigate a videotape depicting the ritualistic murder - and subsequent Undead - of a member of a cult calling themselves "the Deaders". Amy tracks down the return address of the tape and discovers the corpse of its sender, Marla, holding the Lament Configuration. She returns to her hotel and opens the box, triggering an apparent dream in which she summons Pinhead (Hellraiser) (Doug Bradley). Amy delves into Bucharest's subculture and meets Joey, who warns her about the Deaders and notices that Amy has a 'self destructive thing'.
The film introduces a circle of youths who are addicted to playing ''Hellworld'', an online computer game based on the Hellraiser (film series). The film opens at the funeral of Adam, one of their friends who was obsessed with the game and ultimately committed suicide after becoming too immersed in the game. The remaining five friends blame themselves for not having prevented Adam's suicide.
Steven Craven and Nico Bradley run away from home and travel to Mexico. They film themselves engaging in several days' worth of drunken partying. The boys later disappear. The Mexican authorities return their belongings to their parents, including a videotape made by Steven that documents their final moments.
Detectives Sean and David Carter are on the case to find a gruesome serial killer terrorizing the city. Joining forces with Detective Christine Egerton, they dig deeper into a spiraling maze of horror that may not be of this world.