Raised by his mother, Rhoda, a high school teacher. Phifer's acting career began when he auditioned at an open casting call for director Spike Lee's Clockers and was selected for the leading role. Working alongside Harvey Keitel and Delroy Lindo, he garnered critical acclaim for his compelling performance as Strike, a young New Jersey drug dealer involved in a murder cover-up. Following his impressive screen debut, he appeared in the comedy spoof High School High.
| Movie | Puff, Puff, Pass | 2006 |
| Movie | Business as Usual: The Exploitation of Hip Hop | 2011 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Movie | Nora's Hair Salon II: A Cut Above | 2008 |
| Episode |
Love, Victor The Truth Hurts |
2020 |
| Episode |
Curb Your Enthusiasm The Ski Lift |
2005 |
| Episode |
Homicide: Life on the Street Control |
1996 |
| Episode |
Psych Let's Doo-Wop It Again |
2012 |
| Episode |
Save Our History Voices of Civil Rights |
2005 |
| Episode |
New York Undercover Tough Love |
1996 |
| Episode |
The Wendy Williams Show Divergent |
2014 |
| Episode |
The Ellen DeGeneres Show Paris Hilton/Kathy Hilton/Mekhi Phifer/ Rhoda Phifer |
2005 |
| Episode |
Love, Victor What Happens in Willacoochee… |
2020 |
| Episode |
Love, Victor Sincerely, Rahim |
2021 |
| Episode |
Chelsea Lately Mekhi Phifer |
2014 |
| Episode |
Love, Victor Who the Hell Is B? |
2020 |
| Series | Late Night with Conan O'Brien | 1993 |
| Episode |
Chelsea Lately Mekhi Phifer |
2009 |
| Episode |
Love, Victor Perfect Summer Bubble |
2021 |
| Episode |
Homicide: Life on the Street Fallen Heroes (1) |
1998 |
| Episode |
New York Undercover The Smoking Section |
1995 |
| Episode |
Love, Victor The Morning After |
2021 |
| Episode |
Lie to Me Blinded |
2009 |
| Episode |
Curb Your Enthusiasm Lewis Needs a Kidney |
2005 |
| Episode |
Husbands The Straightening |
2012 |
| Episode |
Punk'd Mike Shinoda, Brandy, Mekhi Phifer |
2004 |
| Episode |
On Air With Ryan Seacrest 3/10/04 |
2004 |
| Episode |
Lie to Me Sacrifice |
2009 |
| Episode |
Love, Victor Day One, Take Two |
2021 |
| Episode |
Love, Victor Close Your Eyes |
2021 |
| Episode |
MADtv Episode #806 |
2002 |
| Episode |
Homicide: Life on the Street Blood Ties (1) |
1997 |
| Episode |
Love, Victor Agent of Chaos |
2022 |
| Episode |
The Ellen DeGeneres Show Melina Kanakaredes/Mekhi Phifer/Jem |
2004 |
| Episode |
Love, Victor Fast Times at Creekwood High |
2022 |
| Episode |
Inside Dish with Rachael Ray Mekhi Phifer |
2004 |
| Episode |
Love, Victor The Gay Award |
2022 |
