Dennis goes into hospital, frightened by ""mis-informed"" medical facts his friends have given. However, when Mr.Wilson accidently winds up as his roommate, he forgets about his own fears, and sets out to ""protect"" his friend. In the end, Mr.Wilson is so distraught and beleagured by Dennis ""care"", that he begs to be put in the isolation of the intensive care unit! Seeing how ""brave"" Mr.Wilson is, Dennis finally musters the courage to let them do his ""tonsil-neck'tamy"" after all.
Dennis decides he's too big for baby-siters and tells Joey it's time they ""became men"". However, duplicating the exact things Mr.Wilson was supposed to have done as a young man, he soon has Margaret on his case, trying to prove a point for all womanhood. Then, when the kids accidentally wind up on a ""camp out"" with Henry and George, the differences escalate into a ""battle of the sexes"" to see who can survive the woodsy ordeal. Hint: Don't put your money on Mr.Wilson.
Dennis wages an all-out commando strike on the neighbourhood bully. But he inadvertently ""captures"" a toothache-ridden Mr.Wilson instead, and the two are stuck together on a wild odyssey to the dentist's office, filled with ""pains, trains and automobiles"". During their trek, Dennis learns a valuble lesson about the true nature of bullies...and manages to sneak in a little impromptu dentistry of his own!