The good news that we are living longer brings with it the bad news that many of us will suffer the ill effects of old age as a result. Maggie Philbin looks at how our muscles and bones change as we get older. Liz Bonnin explains how bones are made and how they weaken with age, then looks at a human brain growing in a petri dish, that could pave the way for a cure to diseases like Alzheimer's. Finally the team are joined by Sir Terry Wogan, who goes on a personal quest to find out if there are any drugs currently available which could reduce his risk of developing dementia.