Betsy is scared enough on her first day of Kindergarten; she doesn't need the responsibility of taking care of the class Salamander, Sydney. But when Betsy loses Sydney and she wants to tell her teacher that she'll try to come back next year for school, her new friends come to her aid and Betsy takes responsibility and tries to find Sydney. Betsy and her classmates visit a Museum. Betsy's curious friend Billy decides to check out another part of the museum that they were not allowed to go to, and Betsy and Billy get lost. They quickly learn about why you should never take off without telling an adult and the rest of the class also learns about how fun museums, and field trips in general, can be.
When Mrs. O'Connor's kindergarten class goes on a field trip to the farm, the class learns all about how cows are milked, what types of food the animals eat and other things about farms. Betsy, though, is embroiled in the mystery of the missing chicks. Every time she goes back to see the cute little baby chicks that just hatched, another one disappears. The whole class visits a nursery and begins to grow their own plants. Betsy's plant, however, is the only one that won't grow. Betsy learns all sorts of different ways to help plants grow, and eventually, Betsy's plant blooms into something truly unique after all. She learns to not doubt herself and that things that may not look so special, may grow into something very beautiful.
It's Betsy's turn to be the class "Weather Watcher" for the week and she's hoping it rains so she can wear her new ducky boots that her Grandma sent her. Everyone in the class must show their way to play and get exercise, but Betsy's not sure in which sport or activity she plays best.
Betsy is afraid to go out in her backyard at night, but when her friends are invited over for a camping sleepover, she is forced to face her fears. In the end, Betsy learns that there was nothing to be afraid of, and she also has learned some good lessons about the solar system. Betsy discovers that she has a loose tooth. After initially not wanting to lose her baby tooth to make way for an adult tooth, Betsy quickly changes her mind when Mrs. O'Connor announces that everyone who has lost a tooth can put their name on the "tooth chart." Now the tooth is overstaying its welcome. Betsy learns about her ever-changing body and that good nutrition is required to help her bones - and teeth - grow.
Betsy and her classmates suspect their teacher is a spy, so they go on an adventure to find out the truth. It's "Show and Tell" week at school and Betsy can't decide what she wants to share with the class.
Betsy is excited to play Mrs. O'Connor's spelling game, although she does not want to get stuck with the dreaded letter "U" - she doesn't think any words contain that letter. After trying to push the letter onto her classmates, she soon realizes that a large amount of words contain the letter "U". Betsy learns a lesson not only about spelling, but how to blend vowel and consonant sounds to correctly say different words. Bus Driver Bob is in charge of making pancakes for the Lakeshore School's Pancake Breakfast and he has lost Principal Warner's pancake recipe. Lucky for him, Betsy remembers the directions of her grandmother's pancake recipe. Everyone learns that the skill of following directions is not only important in the classroom, but also in life in general and for people of any age.
Betsy and her classmates visit the library and learn how it works. They learn all of the rules and regulations of the library as well. So when Betsy thinks she loses her library book, she fears the consequences. Mrs. O'Connor's class learns all about protecting the environment on "Earth Day". Betsy shows the class how to re-use things that you may think were garbage.
When Betsy's Dad's new birdbath decoration turns up missing, everyone suspects their dog, Gracie. But using their five senses, Betsy, Billy and Molly solve the mystery and discover the true culprit. Everybody learns that guessing isn't as good as the facts and that you are innocent until proven guilty. Betsy is worried that no one will be able to come to her birthday party because they all have things to do this week. She isn't sure exactly how everyone's schedule will impact her party, but, fortunately for Betsy, Mrs. O'Connor teaches her all about calendars. She learns how to measure time with a calendar and the proper order of the days of the week.
The class puts on a carnival. Betsy and Scott run the Prizes Booth, but Betsy soon has trouble counting the tickets she receives so the other students can claim their prizes. Betsy and her Mom seem to be late for everything lately. Good thing Mrs. O'Connor teaches Betsy and her class about the concept of time and reading a clock. Betsy soon learns how to use her time more wisely.
When the class learns about measurements and begin to measure their growth, Billy worries that he has stopped growing because he hasn't grown any taller in awhile. The class learns all about the concept of money. Betsy decides she wants to buy her Mom a hair clip, but she needs to figure out how to get money to buy it.
Mrs. O'Connor invites a Postman to the classroom to explain how the Post Office works. Afterwards, the children give out Valentine's Day cards in the classroom just as the Post Office would. Mrs. O'Connor teaches the class about basic food nutrition. Betsy and Billy decide that they will only eat blueberries, because they taste good and are good for you. But after a weekend of eating nothing but blueberries, the kids realize you have to eat well-balanced meals in order to stay healthy.
Mrs. O'Connor teaches the class about animals. The first featured animal is a turtle. They learn a valuable lesson in responsibility and what it takes to care for pets. The children learn to develop an awareness of the world around them as well as development of their imaginations and the ability to recognize landmarks and locations. When their freshly baked "Gingerbread Man" disappears, they need to use all these skills to solve the mystery and find their "Gingerbread Man".
When the class has a bike parade coming up, Molly admits to Betsy that she doesn't know how to ride a bike. With the help of Kenji and Betsy, Molly finally learns how to ride her bike and stars in the parade. After Kenji says giants are causing the sound of thunder, Betsy and her classmates become extremely scared when a storm comes through. Mrs. O'Connor eases their fears with the truth about thunder and lightning and how it really works.
Lakeshore School welcomes a new student, Newton. But when Newton seems scared and nervous, Betsy takes it on herself to show him around and introduce him to all the students. The children need to find "the secret of the primary colors" while making an art project. They cannot decide on what to make, so the boys and girls split up into separate groups and make two separate art projects.
When Betsy and her friends are playing with helium-filled balloons, Betsy mistakenly thinks her baby brother floated away. Mrs. O'Connor's class visits a Firehouse. On their way back to school, Betsy thinks she sees a fire and reports it.
Mrs. O'Connor teaches the class all about responsibilities. After Billy gets an important responsibility, he thinks he will sabotage the assignment to never get another one again. But after a talk from Betsy, Billy decides to do his best when given a responsibility. After the children misbehave on the bus ride to school, Mrs. O'Connor decides to take them back to Bus Driver Bob to learn the rules they should follow on the bus.
The children perform a play about animals and nature. Betsy is very disappointed when she has to play a tree, but the children make her realize that trees are just as important as anything else, and possibly more important. The class visits an Aquarium and learn all about Ocean animals. Kenji is extremely scared with all of the animals, as he is not familiar with them. But with Betsy's help, Kenji comes to realize there's nothing to be afraid of at the Aquarium.
A police officer visits the class and teaches the students all about what the Police do. He also teaches Betsy all about Detective work, which she uses to solve the mystery of who stole Kevin's teddy bear. Mrs. O'Connor teaches the class about how to stay healthy and invites a Doctor to class. Betsy realizes that healthy foods are very tasty, too.
The Super Fun Sandy Mega Play Set is coming out in stores, but Mrs. O'Connor has just given the class homework. Betsy decides the right thing to do is follow the homework rules and finish her work before she goes out and gets the toy, but it may not be available if she gets to the store too late. Mrs. O'Connor brings caterpillars into the class. They learn all about the life cycle of a butterfly and then Mrs. O'Connor lets the class decide what to do with the beautiful butterflies after they're full grown.
The class learns about personal hygiene and germs. Betsy gets a little carried away and learns its best to do everything in moderation. When the class is learning about space, Mrs. O'Connor takes them on a field trip to visit the planetarium.
The class has to get ready for "Parents Day Tea Party", so they all have to learn how to have proper manners. Molly thinks she knows it all, but actually she seems to have very bad manners. The class learns about Sorting and Classifying. Mrs. O'Connor takes the class on a field trip to Lakeshore Farms where things are disappearing. Betsy and her friends solve the mystery by sorting and classifying.
The class learn the difference between big and little. Bus Driver Bob thinks his bus has shrunk into a tiny toy bus when someone moves his bus and it is replaced by Newton's toy bus. Mrs. O'Connor has a surprise for the class in the library. Computer stations have been set up for everyone! The kids have fun learning the basic instructions on how to use a computer.
Betsy has an assignment to make her own musical instrument, but everything she thinks of is already taken by another member of the class. With her father's help, she discovers an instrument and the whole class plays a nice medley together. The class goes on a field trip to the Dinosaur Museum. Not only do they learn about dinosaurs, but also about what a paleontologist does. They have such fun exploring within the museum digging pit as well as at home, digging up things in the backyard of Betsy's house.
The class learn about directions of a map. They learn how to use a compass and nature to complete Mrs. O'Connor exercise to find the treasure. The class get the chance to really understand what it takes to run the school. They each get a set of responsibilities in different departments. Betsy and Newton are the principals. They each come to realize how much work and responsibility goes into running the school and being an adult.
Betsy can't decide what she wants to be when she grows up. The students learn about fiction and nonfiction.
Billy and Sarah both want to lead the Election Day parade. Scott feels bad because he is the slowest and smallest in the class.