Fern, a beautiful blue Burmese and one of the Cat Hospital's oldest patients takes a turn for the worst; Franklin, a prize-winning Maine Coon, is a novice when it comes to females but he meets Ruby; Clare meets a visiting cat called Honey.
A stray cat has been re-named Apple, but needs a "forever home"; Binky is one of the most seriously ill cats that Clare has met; ten-year-old Sparky has terminal cancer.
A stray cat wearing a cone-shaped collar turns out to be living a double life; a highly spirited cat called Charlie gets his annual check up; a sphinx cat called Vader is treated for painful spots on his tummy.
at Catchers Maggie and Jim attempt to round up a colony of farm cats; Harley comes to the hospital for routine checkup; Martina is searching for an effective stress relief for her cat.
Nurse Rachel is going to hand-rear two kittens for the next twelve weeks; new vet Aisling makes her first house call; an emergency call comes in after cat Jessie is hit by a truck.
Animal lover Eilish has been feeding the stray cats in her garden during lockdown, and contacts the clinic when she notices the health of one of them is beginning to deteriorate.
When a young kitten is found abandoned with a major leg injury, Maggie, brings her to foster carer Collette. Clare examines Blue and determines that the leg must be amputated.