One by one, the world's worst organized crime gang, the Monster Mob, go after Detectives Droopy and Dripple./Dweeble hires a junkyard dog to get rid of Screwball Squirrel. The dog is an overachiever who throws out Dweeble and Rumply./Droopy is the famous British Detective Sherlock Droopy. He and Dr. Dripple do battle with the infamous professor Wolfiatity, their arch-nemesis. They stop him in Queen Victoria's bedroom.