Similar to most catchphrases and recurring jokes in The Big Bang Theory, Howard Wolowitz’s relationship with his loud, unseen mother was always played for laughs. But after the real-life passing of actress Carol Ann Susi, the Big Bang Theory was forced to make a difficult decision, and what followed became the most heartbreaking scene the series ever delivered. Proving even the funniest shows can sometimes deliver the most devastating moments. It all started as a joke…But it ended as one of the most emotional moments in sitcom history.