In the first episode, a surgical robot is used to treat a tumour on a patient's voice box, in a procedure that has never been attempted before. Other surgeons must perform a complex procedure to try to save a photographer's arm, and remove new cancer growth in a patient's abdomen.
Professor Vin Paleri must establish if a patient with a fast-growing tumour in his tongue is viable for a complex surgery using tissue from his leg to reconstruct his throat. Specialist Mr Ricky Bhogal performs an intensive procedure to remove a tumour completely from a patient's portal vein, which, if compromised during surgery, would be fatal.
A patient with throat cancer needs a new windpipe to save his voice. A rare cancer means Melissa's entire reproductive system must be removed for her to stay alive.