A prominent doctor goes on the run when he is accused of killing his wife following a home invasion. Kimble flees the scene with U.S. Marshal Samuel Gerard, hot on his heels, but as Kimble begins to eludes the authorities, Gerard starts to realize that things may not be what they seem when it comes to Dr. Richard Kimble.
In New York, security cameras in a United Nations parking garage record two Diplomatic Security Service (DSS) agents attempting to intercept a briefcase exchange between two men. One man kills the agents; the other escapes with top secret information.