Eisuke has been missing since the winter break after he found a clue of the whereabouts of a member of his father's company. Coincidentally, the member is at Haido Central Hospital, where Rena Mizunashi is secretly held at. Conan meets with Jodie who confirms Eisuke has been seen at the hospital and reveals that Eisuke's father was a secret CIA agent who died four years ago by the hands of Rena. Conan follows Jodie to the hospital to search for Eisuke and begins to believe Eisuke might be in trouble because the member of his father's company is really a member of the black organization. Conan talks to a nurse to discover there's a patient in the hospital who is also looking for Rena.
Conan apprend que l'énigmatique Eisuke Hondo est porté disparu par ses camarades de classes, et qu'il a peut-être découvert l'endroit où est cachée Rena Mizunashi. Encore plus inquiétant, un tristement familier numéro de téléphone a été entendu là-bas. Le jeune détective décide de travailler en collaboration avec les agents du FBI pour dénouer ce mystère.
Ran comunica a Conan che Eisuke è irrintracciabile dal giorno in cui aveva affermato di avere incontrato uno dei colleghi del padre. Il giovane detective incontra Jodie, la quale gli racconta di avere scoperto che il padre di Eisuke, Ethan Hondo, era un agente della CIA infiltrato nell'Organizzazione nera
Ran le cuenta a Conan que Eisuke lleva semanas desaparecido y que lo último que le dijo fue que había conseguido una pista. Conan contacta a Jodie y se devela que el padre de Eisuke, Ethan Hondou, era un miembro de la CIA y que lo asesinó Rena Mizunashi hace 4 años. Jodie y Conan deciden ir a ver a Rena al hospital y una vez allí le preguntan a una enfermera sobre Eisuke, esta les advierte que no fue el único en preguntar por Rena.
