Melinda Gordon just got married; during the dinner she sees something being drawn on the window and she knows it's a ghost. But for the first time, the ghost comes inside her house and that unsettles her. Despite being afraid, she tries to help him reunite with his family and pass along the message he needs her to say.
A boy who was killed in a collision with a train wants Melinda's help to ensure his mother that his death was not caused by her.
The identical twin sister of a teenage girl requests Melinda to help her apologize to her sister who is a psychiatric patient.
A man killed in a biking accident seeks Melinda's help to save his fiance's life and finding out who received his heart afterwards.
Melinda encounters the ghosts of three boys who died in the fire of an orphanage. They must cross over prior to the demolition of the building holding them inside.
Melinda helps an angry teenage ghost and discovers the secret that is likely to shake up the ones left behind by him.
In a hospital, Melinda encounters a woman who wants to determine what caused her death during a surgery.
An evil spirit is haunting Jim, causing him to begin doubting his sanity. Melinda must help this spirit, even though he is dangerous, in order to help Jim. .
The spirit of the mother of a teenage boy attempts to communicate with her son via white noise. Melinda must find a way to get her messages across.
A ghost of a bride who didn't make it through her wedding night is back with a vengeance haunting her husband's new fiancée to the point of her leaving him at the alter.
The dead mother of a boxer requests Melinda to assist in getting her son back together with his father. The son is furious because his father caused him not to be able to spent time with his dying mother.
After a stand-up comedian commits suicide, he's left in between worlds. Melinda tries to help him find closure.
The ghost of an elderly man suspects Melinda's new neighbor of killing his granddaughter.
A hanged man's ghost follows Melinda home from a macabre art installation, haunting her into contacting his troubled daughter. A woman sues Melinda's paramedic husband, claiming he further injured her whilst performing life-saving CPR.
Melinda is forced to remember how her relationship with her mother became strained after Melinda’s first ghost emerges. Melinda’s mother could not understand how to deal with Melinda’s gift. Melinda must reunite with her mother to help the ghost.
Andrea’s friend has gone missing during a hike and Melinda’s called in so she can use her abilities to find him.
Melinda comes across the spirit of an infuriated young boy, who's terrorizing his mother and baby sister.
When a traveling circus arrives, Melinda meets the bitter ghost of a magician who accuses his envious brother of his death, deemed to have been accidental.
Melinda must help the ghost of an African-American man who had been attacked and killed by a white co-worker in the 1970's. The ghost is haunting the prosecutor who had enough evidence but still failed to file charges against the white co-worker. Melinda tries to help the ghost find justice and help his son to change his racist views before they're passed on to the next generation.
A head injury caused by an accident puts Melinda's abilities at risk. Melinda must deal with the possibility of permanently losing her gift as she attempts to help a young girl whose boyfriend has recently died.
Melinda experiences a sense of dread when she realizes that a plane is going to crash when the spirits of the pilot and flight attendant contact her.
After a jetliner crashes Melinda faces the overwhelming task of helping hundreds of passengers crossover. While Melinda faces this task she finds that the “Wide Brim Man” is working against her. Melinda must also try to work with the crash investigators who are trying to find out how Melinda knew that the plane was going to crash.
Melinda worries that Andrea is being influenced not to cross over. Melinda seeks the help of an expert in history and the occult in helping to identify the wide brimmed hat man.
A rock and roll enthusiast expands his love to living teens by tormenting them into stealing. Melinda must also deal with the ghost of her scheming ex-boyfriend.
When Melinda goes to visit friends who are experiencing problems with their house, she finds the ghost of six-year-old little girl who drowned. Melinda then tries to help the family of the little girl.
After purchasing a set of ornaments at a flea market, Melinda finds that they are haunted. Melinda uses the ornaments to meet Dennis’s ghost. Dennis wants Melinda to reunite his girlfriend with her birth mother.
The ghost of a man who was buried in the wrong grave starts to haunt a cemetery as someone else’s wife is coming to mourn him every night. Melinda must reconcile the man with his hostile wife and daughter in order for him to be able to cross-over.
Jim has a ghost who died during surgery come to his dreams. Melinda and Jim find that the ghost, a supermodel, cannot cross-over as she wants to save her little sister from suffering the same destiny. Jim's friends are frightened by the crazy events that occur at his house.
Melinda and Jim's first camping trip is interrupted as Melinda helps the ghost of a woman who left her husband and young daughter. Before the woman can cross over Melinda must find the woman’s daughter and help her to learn the truth about her parent’s past in order for her to be safe now.
The ghost of chef who died in a fire at a Chinese restaurant meets Melinda after the restaurant he died in burns for a second time. He demands that Melinda go out and find the person that really set the fire he was blamed for.
When Melinda meets a nightclub waiter who has not played his guitar since his friend died, she finds that he is being haunted by two ghosts.
A high school baseball pitcher Justin finds that he is haunted by the former baseball star pitcher. The ghost is out for revenge on the coach who he blames for his death.
While Melinda is at the University’s botany lab she deals with some telekinetic events while dealing with a plant from Peru that is bleeding. Melinda finds that she must help a Doctor save herself.
Melinda has trouble talking to a ghost only to find that it's because he is not dead but is in a coma. While Lisa, his wife is in a legal battle against his parents to take him off of the life support. Meanwhile Delia struggles with teaching Ned about closure while also finding closure for herself.
Melinda finds that she must stop a ghost who doesn't want to be reincarnated again. Melinda finds out that someone knows her secret. Delia has second thoughts about dinner date.
Melinda's Jeep breaks down on a deserted road and a young woman who owns an auto shop comes by to help. Melinda meets a ghost who comes to her in the form of a skeleton. Melinda must first decipher the mysterious code that is linked to the drag racing society. Melinda finds that Ned is involved with the society and needs his help. Ned lies to his mom and sneaks out to go to the drag races. At the end the ghost finds closure and crosses over into the light.
Melinda gives a speech on her career at Grandview High. While she’s at the school she sees a group of cheerleaders who are having some mean and vicious things happening to them just as their cheerleading semi-finals are approaching in just a few days. Melinda discovers that the dead cheerleader can’t cross over and someone else has been casting spells on the squad.
Melinda accompanies Delia to the local jewelry store so she can get her newly refurbished engagement ring. An armed robbery occurs while they are in the jewelers. Later, the ghost of jewelry salesman visits Melinda and she must help him make things right again.
A body goes missing from the morgue and Melinda searches for the body. When the ghost visits Melinda she finds she needs help from Professor Payne to figure it out.
Melinda and Jim become foster parents temporarily for a young girl whose mother is missing. The ghost of the mother comes to Melinda and tells her where Melinda can find her body. The mother confesses a secret to Melinda and Melinda and Jim set out to help the little girl.
Melinda helps Ned deal with a ghost who had just put a scare into him. Melinda also helps a ghost who appears to without any clothes on. Delia sees that Melinda is once again talking to herself and Melinda decides it’s time to share her gift with Delia.
Melinda meets a man who has the same abilities to see and talk to the dead. Melinda later learns that he has a different plan for the dead. A ghost enlists Professor Payne to help Melinda.
Five accidents, and four signs, something else is going to happen. Melinda becomes concerned for the safety of the people she loves when a ghost prophet shows her visions of the future. The fellow Ghost Whisperer, who Melinda doesn't trust is still in Grandview.
Melinda visits the Mayor of Grandview and asks him to cancel the memorial dedication they are holding. She speaks to the ghost of a mail person and is looking for a young girl named Kristen. Later, Melinda and Professor Payne search for missing children after their Nanny says that they left with a man named Gabriel. Meanwhile, a mysterious man tries to get Melinda to stop helping the good guys.
