Dorothy's daughter, Kate, comes to Miami with an announcement. She's engaged to a podiatrist named Dennis. Dorothy is thrilled but her happiness quickly turns to anger when she realizes that ex-husband, Stan, is going to be invited. After 38 years of marriage, Stan had left Dorothy for a woman half her age. Dorothy threatens to make a scene at the reception which places Rose and Blanche in the role of peacemaker.
After a Madonna concert, the girls arrive home to discover their house has been broken into. This leads the girls to seek out means to protect themselves, including a security system, guard dog and mace. Meanwhile, Rose becomes so paranoid that the robbers will come back she goes so far as to purchase a gun.
Blanche's psychology professor sexually harasses her when she goes to him for help on a difficult test. Blanche's professor makes her an harassing deal: If she has sex with him, he'll give her an "A" for the exam. Meanwhile, Dorothy, Rose and Sophia each try to get a hold of tickets for a sold out Frank Sinatra concert.
The house is fumigated and the girls move into a Miami Beach hotel. Previously, Blanche had won three tickets to see the opening of Burt Reynolds new movie and passes to the party held afterwards where they could meet him. However, on the evening of the opening, the hotel is raided and, mistaken as prostitutes, Dorothy, Blanche and Rose are dragged off to jail.
Dorothy's daughter, Kate is coming for a visit and has a big announcement. Dorothy is excited when she thinks the announcement is going to be that Kate is pregnant. However, when Kate arrives, her announcement is far from exciting. Meanwhile, Blanche and Rose stay up and watch an "I Love Lucy" marathon.
Sophia got the girls a chance to appear on a hit game show Grab that Dough in California. At the hotel, they miss their reservations and they must sleep in the lobby...as a result, all their personal belongings are stolen. Sophia still has the tickets but once they arrive to the game, the girls fight and split into two separate competing teams.
This episode does a study in contrast, Sophia's busy day to Blanche, Dorothy and Rose's lazy day. While Sophia, organizes a band to raise money, volunteers at the hospital and battles return policies at the supermarket, Blanche, Dorothy and Rose sit around discussing what they should do that's constructive.
The death of a close friend, Esther Weinstock, brings Sophia face to face with Esther's husband a man whom she vowed never to speak to again due to things that happened in the past. However, when Dorothy prompts them to make up they get a little to close and wind up in bed together. Soon after, they announce their engagement, something that Dorothy is totally against. Meanwhile, Blanche and Rose begin a Elvis Presley fan club.
The search is on for the missing winning lottery ticket that would give the girls $10,000. The girls had put it in the pocket of an aviator jacket, which Sophia mistook as an item to go to a thrift shop. The search leads the girls to the thrift shop then to a celebrity auction and finally to a homeless shelter.
The girls try to cough up enough money to pay for a new roof. Meanwhile, Sophia's volunteer job at the hospital is what brings the girls a piece of inside information that could give them enough money for a new roof and money left to spare. The info is that a famous artist is dying, so the girls head to an auction to bid on one of his paintings.
Sophia's old friends, Philomena and Dominic, come to Miami from Sicily, for a visit and have shocking news for Dorothy. Philomena and Sophia had met in the hospital when they were giving birth and now Philomena and Dominic claim that there was a mix-up and Dorothy was switched at birth. Meanwhile, Blanche and Rose take "dirty dancing" lessons.
When the company that Rose's husband worked for, cuts off their pension plan, Rose must face the fact that she's going to get a new job, one that pays more. However, she quickly finds herself dealing with something she never expected, age discrimintion. Meanwhile, Sophia goes wild buying things in quantity at a Shopper's Warehouse.
Dorothy finds a list of things that she wanted to accomplish before a certain age and finds that she hasn't accomplished many of them. So she decides to go after one of them, entertaining people. This leads her to sign up to do a stand up routine at a nightclub. Meanwhile, Blanche finds herself battling the IRS.
Dorothy's son, Michael, shows up on her doorstep with news that he's separated with his wife and needs a place to stay. However, Dorothy quickly gets tired of his freeloading and dumps him on Stan. Meanwhile, Rose's stress is getting terrible and is reluctant to talk to her boss about cutting back on her "things-to-do" list.
Dorothy becomes alarmed when Sophia forgets the date of her wedding anniversary. This leads Dorothy to face the fact that Sophia is becoming more and more forgetful with age. After visiting a doctor, Sophia decides to regain some of the memories she has lost and decides to take a trip to Brooklyn and their old apartment.
Rose discovers that she may be carrying the HIV virus after learning the blood they used in her gallbladder operation may have contained HIV antibodies. What really gets to her though is the 72 hours she must wait before hearing the test results. Meanwhile, Dorothy organizes a Save the Swamplands charity.
Both Sophia and Rose take advice from Blanche that lands each of them in hot water. Due to a drought in St. Olaf, Rose swears to be celibate and Blanche advises her not to tell Miles the truth. While Sophia takes Blanche's tips to lure a man to bed but when she tells him she loves him, he doesn't respond with what she hoped.
It is the annual "Buy Sophia New Shoes" day, and Dorothy is forced to take her. Blanche also tags along, mentioning that it might be fun. Meanwhile, Uncle Angelo drops by and Rose is there. Since she is trying to find a good story to report on, she is more than happy to hear Angelo's story. Apparently, his apartment building is infested with huge bugs. When the ladies watch the news, Rose insists they watch the news story about the bugs. Dorothy then tells Rose she and Stan are the landlords. Rose then tells her she didn't realize there was a family side to the story. She won't give up on the story, and a minute later, the cops show up to arrest Dorothy. They have a trial, and Stan drops his attorney for a younger woman who knows nothing. The defense lawyer is unbeatable by giving compliments to the witnesses which makes them vulnerable to his advantage. Stan and Dorothy end up losing and are forced to live in a sleasy apartment building for a while.
Rose is upset when she has missed her high school reunion due to being sick, so Blanche convinces her, Dorothy and Sophia to crash a reunion held in Miami, posing as absentees from that school. Dorothy goes as the lame prom queen Cindy Lou Peoples, Blanche is the seemingly slutty Susan, Rose is the Korean exchange student Kim FongToi and Sophia is Mrs. Gonzales. With that, the girls mingle with their "former" classmates, only to realize that their counterparts lives are as dull as theirs, however, when the girls are found out by the guests...Rose has a heart attack!
While Rose undergoes severe surgery, the girls try to entertain themselves with fond memories and laughter, only for Rose's daughter Kirsten to walk in on them enjoying themselves! Kirsten is spiteful of them and does not allow them to visit Rose. Kirsten visits Rose, who is near knocked out, and try to have a conversation...very comically as poor Rose is not altogether. With Rose going into surgery, Kirsten reconciles with the worried girls. At last, Rose is released and they all throw a surprise welcome home party for our lovable St. Olafian!
Blanche's uncle Lucas Hollingsworth is visiting but, to no surprise, Blanche is busy with a date. In order to berid of his intrudence, Blanche tells Dorothy that he desparetely wants to meet a woman of her intelligence. Dorothy agrees to see him but they both later learn that Blanche just lied to get rid of them and decide to get revenge by acting as though they're getting married, much to the dismay of Blanche. As a result, Rose decides she should move on to live with her daughter Kirsten to be the "Sophia of the household" as Blanche finally comes to terms with their idea to wed. Just as Lucas is about to reveal the truth, he decides to pop the question to Dorothy for real...
Dorothy accepts Lucas' proposal. The two plan to tie the knot two months later and on the way to the chapel, Dorothy takes a limo. However, this limo is driven by none other than Stanley Zbornak. The two share a rather comical but nonetheless touching moment together before arriving at the chapel. Down the aisle, along with Sophia, the girls think to themselves about the beautiful friendship they shared. Rose, Blanche and Sophia decide that the three of them should not depart and allow Dorothy on her way to Atlanta but she doesn't leave without sharing some final words with the girls...